Display options
Cite
Bloom RD, Crutchlow MF. New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies. Clin J Am Soc Nephrol. 2008;3:S38-48doi: 10.2215/CJN.02650707.
Bloom, R. D., & Crutchlow, M. F. (2008). New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies. Clinical journal of the American Society of Nephrology : CJASN, 3S38-48. https://doi.org/10.2215/CJN.02650707
Bloom, Roy D, and Crutchlow, Michael F. "New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies." Clinical journal of the American Society of Nephrology : CJASN vol. 3 (2008): S38-48. doi: https://doi.org/10.2215/CJN.02650707
Bloom RD, Crutchlow MF. New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies. Clin J Am Soc Nephrol. 2008 Mar;3:S38-48. doi: 10.2215/CJN.02650707. PMID: 18309002; PMCID: PMC3152270.
Copy Download .nbib Format: NLM
Share it on

Clin J Am Soc Nephrol. 2008 Mar;3:S38-48. doi: 10.2215/CJN.02650707.

New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies.

Clinical journal of the American Society of Nephrology : CJASN

Roy D Bloom, Michael F Crutchlow

Affiliations

  1. Renal Electrolyte and Hypertension Division, University of Pennsylvania, Founders Building, First Floor, 3400 Spruce Street, Philadelphia, PA 19104, USA. [email protected]

PMID: 18309002 PMCID: PMC3152270 DOI: 10.2215/CJN.02650707

Abstract

Advancing care has markedly improved survival after kidney transplantation, leaving patients susceptible to the effects of chronic transplant-associated morbidities. New-onset diabetes mellitus (NODM) is common in kidney recipients, threatening health and longevity by predisposing to microvascular and cardiovascular disease and by reducing graft survival. A strong rationale therefore exists for the aggressive treatment of NODM in kidney recipients to limit these complications. Screening for diabetes should be systematic and should span the pre- and posttransplantation periods. Once NODM is diagnosed in the kidney transplant patient, a comprehensive plan of therapy should be used to achieve treatment targets. As in the general population, treatment includes lifestyle modification and drug therapy as needed, but transplant-specific factors add complexity to the care of kidney recipients. Among these, minimizing immunosuppression-related toxicity without compromising graft outcomes is of paramount importance. Preexisting allograft functional impairment and the potential for significant interactions with immunosuppressive agents mandate that the expanding armamentarium of hypoglycemic agents be used with care. A team-oriented treatment approach that capitalizes on the collective expertise of transplant physicians, diabetologists, nurse-educators, and dieticians will optimize both glycemic control and the overall health of hyperglycemic kidney recipients.

References

  1. JAMA. 2002 Dec 4;288(21):2709-16 - PubMed
  2. Semin Dial. 2004 Sep-Oct;17(5):365-70 - PubMed
  3. Am J Hypertens. 2003 Nov;16(11 Pt 1):952-8 - PubMed
  4. N Engl J Med. 2000 Feb 10;342(6):381-9 - PubMed
  5. Am J Transplant. 2006 Apr;6(4):842-6 - PubMed
  6. N Engl J Med. 1993 Sep 30;329(14):977-86 - PubMed
  7. Kidney Int. 2002 Oct;62(4):1440-6 - PubMed
  8. Nephron. 1975;15(3-5):306-26 - PubMed
  9. J Am Soc Nephrol. 2002 May;13(5):1374-80 - PubMed
  10. Diabetes Care. 2005 May;28(5):1083-91 - PubMed
  11. Horm Metab Res. 2006 Jun;38(6):423-8 - PubMed
  12. Diabetes Care. 2003 Aug;26(8):2261-7 - PubMed
  13. N Engl J Med. 2005 Dec 22;353(25):2643-53 - PubMed
  14. Diabetes Care. 2004 Nov;27(11):2628-35 - PubMed
  15. Clin Pharmacokinet. 1996 Aug;31(2):111-9 - PubMed
  16. Diabetes Care. 2006 Jan;29 Suppl 1:S4-42 - PubMed
  17. Am J Transplant. 2004 Dec;4(12):2135-8 - PubMed
  18. Am J Clin Nutr. 1999 Apr;69(4):632-46 - PubMed
  19. Diabetes Obes Metab. 2006 Jul;8(4):419-28 - PubMed
  20. Diabetes Metab Res Rev. 2001 May-Jun;17(3):181-8 - PubMed
  21. Diabetes Care. 1999 Jun;22(6):925-7 - PubMed
  22. Transplant Proc. 2000 May;32(3):580-2 - PubMed
  23. Clin Transplant. 2005 Jun;19(3):291-8 - PubMed
  24. Diabetologia. 2006 Nov;49(11):2564-71 - PubMed
  25. Ann N Y Acad Sci. 2002 Apr;958:7-25 - PubMed
  26. Lancet. 1998 Sep 12;352(9131):837-53 - PubMed
  27. J Clin Endocrinol Metab. 2003 Feb;88(2):576-80 - PubMed
  28. Transplantation. 2005 Nov 27;80(10):1402-5 - PubMed
  29. Lancet. 2005 Oct 8;366(9493):1279-89 - PubMed
  30. Endocrinology. 1995 Aug;136(8):3585-96 - PubMed
  31. J Am Soc Nephrol. 2004 Dec;15(12):3233-9 - PubMed
  32. Diabetes Care. 2007 Jan;30 Suppl 1:S4-S41 - PubMed
  33. Am J Transplant. 2004 Oct;4(10):1675-83 - PubMed
  34. N Engl J Med. 2001 Nov 8;345(19):1359-67 - PubMed
  35. Diabetes Care. 2001 Jul;24(7):1226-32 - PubMed
  36. Transplantation. 1997 Apr 15;63(7):977-83 - PubMed
  37. Transplantation. 2000 Mar 15;69(5):834-41 - PubMed
  38. Diabetes Care. 2001 Apr;24(4):683-9 - PubMed
  39. Lancet. 2006 Sep 23;368(9541):1096-105 - PubMed
  40. Cell. 2005 Dec 16;123(6):993-9 - PubMed
  41. Ann Pharmacother. 2006 Jul-Aug;40(7-8):1336-43 - PubMed
  42. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD002967 - PubMed
  43. Transplantation. 2004 Apr 15;77(7):1009-14 - PubMed
  44. Diabetologia. 2004 Sep;47(9):1550-6 - PubMed
  45. Kidney Int. 2005 Jun;67(6):2415-21 - PubMed
  46. J Am Diet Assoc. 2003 Jul;103(7):827-31 - PubMed
  47. Int J Artif Organs. 2007 Feb;30(2):118-23 - PubMed
  48. Lancet. 1999 Aug 21;354(9179):617-21 - PubMed
  49. Clin J Am Soc Nephrol. 2007 Mar;2(2):343-55 - PubMed
  50. J Am Soc Nephrol. 2003 Aug;14(8):2092-8 - PubMed
  51. Diabetes Care. 2004 Sep;27(9):2266-71 - PubMed
  52. N Engl J Med. 2007 Jun 14;356(24):2457-71 - PubMed
  53. Transplantation. 2001 May 27;71(10):1417-23 - PubMed
  54. Am J Transplant. 2007 Jun;7(6):1506-14 - PubMed
  55. Lancet. 1998 Sep 12;352(9131):854-65 - PubMed
  56. Am J Gastroenterol. 2003 Jan;98(1):175-9 - PubMed
  57. J Am Soc Nephrol. 2005 Oct;16(10):3128-35 - PubMed
  58. BMJ. 1994 May 21;308(6940):1323-8 - PubMed
  59. Ann Intern Med. 2004 Feb 3;140(3):167-74 - PubMed
  60. Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):747-52 - PubMed
  61. N Engl J Med. 2005 Jan 13;352(2):174-83 - PubMed
  62. JAMA. 2003 May 21;289(19):2560-72 - PubMed
  63. Am J Transplant. 2005 Dec;5(12):2922-8 - PubMed
  64. Clin J Am Soc Nephrol. 2006 Jan;1(1):100-8 - PubMed
  65. Diabetes Care. 2002 Mar;25(3):608-13 - PubMed
  66. Transplantation. 1998 May 27;65(10):1399-400 - PubMed
  67. Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):88-97 - PubMed
  68. Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):483-91 - PubMed
  69. J Hum Hypertens. 1996 Oct;10(10):683-9 - PubMed
  70. Diabetes Care. 2005 May;28(5):1092-100 - PubMed
  71. Am J Kidney Dis. 2006 Jul;48(1):134-42 - PubMed
  72. Diabetes Care. 2006 Sep;29(9):2140-57 - PubMed
  73. Lancet. 2007 Jun 2;369(9576):1834 - PubMed
  74. Transplantation. 2003 May 27;75(10 Suppl):SS3-24 - PubMed
  75. Am J Transplant. 2003 May;3(5):590-8 - PubMed
  76. Coron Artery Dis. 2001 Aug;12(5):413-23 - PubMed
  77. JAMA. 2001 May 16;285(19):2486-97 - PubMed
  78. J Am Soc Nephrol. 2003 Jul;14(7):1880-8 - PubMed
  79. Exp Clin Endocrinol Diabetes. 2003 Oct;111(7):405-14 - PubMed
  80. Am J Transplant. 2006;6(5 Pt 2):1153-69 - PubMed
  81. Transplantation. 2000 Mar 15;69(5):875-80 - PubMed
  82. Ann Intern Med. 1989 Nov 15;111(10):788-96 - PubMed
  83. Diabetes. 1991 Jul;40(7):796-9 - PubMed
  84. Am J Health Syst Pharm. 2005 Jan 15;62(2):173-81 - PubMed
  85. Int J Biochem Cell Biol. 2006;38(5-6):845-59 - PubMed
  86. Am J Transplant. 2003 Feb;3(2):178-85 - PubMed
  87. Diabetes Care. 2004 Dec;27(12):2874-80 - PubMed
  88. Diabetologia. 1984 Sep;27(3):351-7 - PubMed
  89. Diabetes Res Clin Pract. 2005 May;68(2):104-10 - PubMed
  90. Transpl Int. 2005 Apr;18(4):483-6 - PubMed
  91. Clin Transplant. 2001 Apr;15(2):89-94 - PubMed
  92. Transplantation. 1997 Aug 15;64(3):436-43 - PubMed
  93. Am J Transplant. 2005 Nov;5(11):2710-8 - PubMed
  94. Diabetes. 2006 Nov;55(11):3151-9 - PubMed

MeSH terms

Publication Types

Grant support