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Sorenmo KU, Goldschmidt M, Shofer F, et al. Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time. Vet Comp Oncol. 2003;1(1):48-56doi: 10.1046/j.1476-5829.2003.00007.x.
Sorenmo, K. U., Goldschmidt, M., Shofer, F., Goldkamp, C., & Ferracone, J. (2003). Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time. Veterinary and comparative oncology, 1(1), 48-56. https://doi.org/10.1046/j.1476-5829.2003.00007.x
Sorenmo, K U, et al. "Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time." Veterinary and comparative oncology vol. 1,1 (2003): 48-56. doi: https://doi.org/10.1046/j.1476-5829.2003.00007.x
Sorenmo KU, Goldschmidt M, Shofer F, Goldkamp C, Ferracone J. Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time. Vet Comp Oncol. 2003 Mar;1(1):48-56. doi: 10.1046/j.1476-5829.2003.00007.x. PMID: 19379330.
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Vet Comp Oncol. 2003 Mar;1(1):48-56. doi: 10.1046/j.1476-5829.2003.00007.x.

Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time.

Veterinary and comparative oncology

K U Sorenmo, M Goldschmidt, F Shofer, C Goldkamp, J Ferracone

Affiliations

  1. University of Pennsylvania School of Veterinary Medicine, Departments of Clinical Studies and Pathobiology, Philadelphia, PA 19104-6010, USA. [email protected]

PMID: 19379330 DOI: 10.1046/j.1476-5829.2003.00007.x

Abstract

The purpose of this study was to characterize canine prostate cancer using immunohistochemical staining specific for acinar and urothelial/ductal tissue and correlate these results with the dogs' castration status/castration time. Seventy dogs with prostate cancer were included, 71% were castrated and 29% were intact. Compared with an age-matched control population, castrated dogs were at increased risk of prostate cancer, odds ratio 3.9. Immunohistochemical staining was performed on 58 cases. Forty-six of the 58 stained positive for cytokeratin 7 (CK 7) (ductal/urothelial origin) and one of the 58 stained positive for prostate-specific antigen. Dogs with CK 7-positive tumours were younger when castrated than dogs with CK 7-negative tumours, 2 versus 7 years (P = 0.03); dogs castrated at

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