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Nandakumar S, Miller CW, Kumaraguru U. T regulatory cells: an overview and intervention techniques to modulate allergy outcome. Clin Mol Allergy. 2009;7:5doi: 10.1186/1476-7961-7-5.
Nandakumar, S., Miller, C. W., & Kumaraguru, U. (2009). T regulatory cells: an overview and intervention techniques to modulate allergy outcome. Clinical and molecular allergy : CMA, 75. https://doi.org/10.1186/1476-7961-7-5
Nandakumar, Subhadra, et al. "T regulatory cells: an overview and intervention techniques to modulate allergy outcome." Clinical and molecular allergy : CMA vol. 7 (2009): 5. doi: https://doi.org/10.1186/1476-7961-7-5
Nandakumar S, Miller CW, Kumaraguru U. T regulatory cells: an overview and intervention techniques to modulate allergy outcome. Clin Mol Allergy. 2009 Mar 12;7:5. doi: 10.1186/1476-7961-7-5. PMID: 19284628; PMCID: PMC2664789.
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Clin Mol Allergy. 2009 Mar 12;7:5. doi: 10.1186/1476-7961-7-5.

T regulatory cells: an overview and intervention techniques to modulate allergy outcome.

Clinical and molecular allergy : CMA

Subhadra Nandakumar, Christopher Wt Miller, Uday Kumaraguru

Affiliations

  1. Department of Microbiology, College of Medicine, East Tennessee State University, Johnson City, TN-37614, USA. [email protected].

PMID: 19284628 PMCID: PMC2664789 DOI: 10.1186/1476-7961-7-5

Abstract

Dysregulated immune response results in inflammatory symptoms in the respiratory mucosa leading to asthma and allergy in susceptible individuals. The T helper type 2 (Th2) subsets are primarily involved in this disease process. Nevertheless, there is growing evidence in support of T cells with regulatory potential that operates in non-allergic individuals. These regulatory T cells occur naturally are called natural T regulatory cells (nTregs) and express the transcription factor Foxp3. They are selected in the thymus and move to the periphery. The CD4 Th cells in the periphery can be induced to become regulatory T cells and hence called induced or adaptive T regulatory cells. These cells can make IL-10 or TGF-b or both, by which they attain most of their suppressive activity. This review gives an overview of the regulatory T cells, their role in allergic diseases and explores possible interventionist approaches to manipulate Tregs for achieving therapeutic goals.

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