Int J Mol Sci. 2008 Apr;9(4):578-605. doi: 10.3390/ijms9040578. Epub 2008 Apr 18.
International journal of molecular sciences
Stoycho D Stoev
PMID: 19325772 PMCID: PMC2635690 DOI: 10.3390/ijms9040578
Various etiological factors contributing to the development of mycotoxic nephropathy in farm animals and humans are reviewed. The possible synergistic effect between ochratoxin A (OTA) and other mycotoxins, as penicillic acid (PA) and fumonisin B(1) (FB(1)), contributing to this nephropathy is also considered and discussed. The most convenient ways of prophylaxis and various preventive measures against OTA contamination of feeds or foods are reviewed. A reference is made concerning the most successful methods of veterinary hygiene control in the slaughterhouses in order to prevent the entering of OTA in commercial channels with a view to human health. The economic efficacy of these prophylactic procedures is also considered. An evaluation of human exposure to OTA is made.
Keywords: BEN - Balkan endemic nephropathy; Balkan endemic nephropathy; FB1 - fumonisin B1; MAN - mycotoxic avian nephropathy; MN - mycotoxic nephropathy; MNFA - mycotoxic nephropathy in farm animals; MPN - mycotoxic porcine nephropathy; OTA - ochratoxin A; OTα - ochratoxin α; PA - penicillic acid; fumonisin B1; hygiene control; mycotoxic nephropathy; ochratoxin A; pathogenesis; penicillic acid; preventive measures; synergism