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Budman SH, Grimes Serrano JM, Butler SF. Can abuse deterrent formulations make a difference? Expectation and speculation. Harm Reduct J. 2009;6:8doi: 10.1186/1477-7517-6-8.
Budman, S. H., Grimes Serrano, J. M., & Butler, S. F. (2009). Can abuse deterrent formulations make a difference? Expectation and speculation. Harm reduction journal, 68. https://doi.org/10.1186/1477-7517-6-8
Budman, Simon H, et al. "Can abuse deterrent formulations make a difference? Expectation and speculation." Harm reduction journal vol. 6 (2009): 8. doi: https://doi.org/10.1186/1477-7517-6-8
Budman SH, Grimes Serrano JM, Butler SF. Can abuse deterrent formulations make a difference? Expectation and speculation. Harm Reduct J. 2009 May 29;6:8. doi: 10.1186/1477-7517-6-8. PMID: 19480676; PMCID: PMC2694768.
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Harm Reduct J. 2009 May 29;6:8. doi: 10.1186/1477-7517-6-8.

Can abuse deterrent formulations make a difference? Expectation and speculation.

Harm reduction journal

Simon H Budman, Jill M Grimes Serrano, Stephen F Butler

Affiliations

  1. Inflexxion, Inc., Newton, Massachusetts, USA. [email protected]

PMID: 19480676 PMCID: PMC2694768 DOI: 10.1186/1477-7517-6-8

Abstract

It is critical that issues surrounding the abuse and misuse of prescription opioids be balanced with the need for these medications for the treatment of pain. One way to decrease the abuse of prescription opioid medications is to develop abuse deterrent formulations (or ADFs) that in some way prevent drug abusers from extracting out the active ingredient in order to employ alternate routes of administration, such as injection, snorting, and smoking. Several factors including the pharmacokinetic profile of the drug, the features of the drug formulation that make it attractive or unattractive for abuse, the type of drug abuser, the progression of one's addiction pathway, and one's social environment may all play a role in the abuse of prescription opioids and what methods are used to abuse these drugs. This paper will examine these factors in order to understand how they affect the abuse of prescription opioids and routes of administration, and how the development of ADFs may alter these patterns.

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