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Hammerman MR. Pancreas and kidney transplantation using embryonic donor organs. Organogenesis. 2004;1(1):3-13doi: 10.4161/org.1.1.1008.
Hammerman, M. R. (2004). Pancreas and kidney transplantation using embryonic donor organs. Organogenesis, 1(1), 3-13. https://doi.org/10.4161/org.1.1.1008
Hammerman, Marc R. "Pancreas and kidney transplantation using embryonic donor organs." Organogenesis vol. 1,1 (2004): 3-13. doi: https://doi.org/10.4161/org.1.1.1008
Hammerman MR. Pancreas and kidney transplantation using embryonic donor organs. Organogenesis. 2004 Jul;1(1):3-13. doi: 10.4161/org.1.1.1008. PMID: 19521554; PMCID: PMC2633668.
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Organogenesis. 2004 Jul;1(1):3-13. doi: 10.4161/org.1.1.1008.

Pancreas and kidney transplantation using embryonic donor organs.

Organogenesis

Marc R Hammerman

PMID: 19521554 PMCID: PMC2633668 DOI: 10.4161/org.1.1.1008

Abstract

One novel solution to the shortage of human organs available for transplantation envisions 'growing' new organs in situ. This can be accomplished by transplantation of developing organ anlagen/primordia. We and others have shown that renal anlagen (metanephroi) transplanted into animal hosts undergo differentiation and growth, become vascularized by blood vessels of host origin and exhibit excretory function. Metanephroi can be stored for up to 3 days in vitro prior to transplantation with no impairment in growth or function post-implantation. Metanephroi can be transplanted across both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. Similarly, pancreatic anlagen can be transplanted across concordant and highly disparate barriers, and undergo growth, differentiation and secrete insulin in a physiological manner following intra-peritoneal placement. Implantation of the embryonic pancreas, is followed by selective differentiation of islet components. Here we review studies exploring the potential therapeutic applicability for organogenesis of the kidney or endocrine pancreas.

Keywords: cell therapy; diabetes mellitus; end-stage renal disease; metanephros; organogenesis; xenotransplantation

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