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Rogers SA, Hammerman MR. Prolongation of life in anephric rats following de novo renal organogenesis. Organogenesis. 2004;1(1):22-5doi: 10.4161/org.1.1.1009.
Rogers, S. A., & Hammerman, M. R. (2004). Prolongation of life in anephric rats following de novo renal organogenesis. Organogenesis, 1(1), 22-5. https://doi.org/10.4161/org.1.1.1009
Rogers, Sharon A, and Hammerman, Marc R. "Prolongation of life in anephric rats following de novo renal organogenesis." Organogenesis vol. 1,1 (2004): 22-5. doi: https://doi.org/10.4161/org.1.1.1009
Rogers SA, Hammerman MR. Prolongation of life in anephric rats following de novo renal organogenesis. Organogenesis. 2004 Jul;1(1):22-5. doi: 10.4161/org.1.1.1009. PMID: 19521556; PMCID: PMC2633670.
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Organogenesis. 2004 Jul;1(1):22-5. doi: 10.4161/org.1.1.1009.

Prolongation of life in anephric rats following de novo renal organogenesis.

Organogenesis

Sharon A Rogers, Marc R Hammerman

Affiliations

  1. Renal Division; Departments of Medicine and Cell Biology and Physiology; Washington University School of Medicine; St. Louis, Missouri USA.

PMID: 19521556 PMCID: PMC2633670 DOI: 10.4161/org.1.1.1009

Abstract

One solution to the shortage of human organs available for transplantation envisions growing new organs in situ. This can be accomplished by transplantation of developing organ anlagen/primordia. Allotransplantation of embryonic day 15 metanephroi into the omentum of adult hosts is followed by differentiation, growth, vascularization and function of the implants. Here we show that survival of rats with all native renal mass removed can be increased by prior metanephros transplantation and ureteroureterostomy. Excretion of urine formed by metanephroi is prerequisite for enhanced survival. This is the first demonstration that life can be extended following de novo renal organogenesis.

Keywords: cell therapy; end-stage renal disease; kidney; metanephros; transplantation

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