Display options
Cite
Campos de Carvalho AC, Goldenberg RC, Jelicks LA, et al. [Not Available]. Interdiscip Perspect Infect Dis. 2009;2009:484358doi: 10.1155/2009/484358.
Campos de Carvalho, A. C., Goldenberg, R. C., Jelicks, L. A., Soares, M. B., Dos Santos, R. R., Spray, D. C., & Tanowitz, H. B. (2009). [Not Available]. Interdisciplinary perspectives on infectious diseases, 2009484358. https://doi.org/10.1155/2009/484358
Campos de Carvalho, Antonio C, et al. "[Not Available]." Interdisciplinary perspectives on infectious diseases vol. 2009 (2009): 484358. doi: https://doi.org/10.1155/2009/484358
Campos de Carvalho AC, Goldenberg RC, Jelicks LA, Soares MB, Dos Santos RR, Spray DC, Tanowitz HB. [Not Available]. Interdiscip Perspect Infect Dis. 2009;2009:484358. doi: 10.1155/2009/484358. Epub 2009 Jun 11. PMID: 19547703; PMCID: PMC2696023.
Copy Download .nbib Format: NLM
Share it on

Interdiscip Perspect Infect Dis. 2009;2009:484358. doi: 10.1155/2009/484358. Epub 2009 Jun 11.

[Not Available].

Interdisciplinary perspectives on infectious diseases

Antonio C Campos de Carvalho, Regina C S Goldenberg, Linda A Jelicks, Milena B P Soares, Ricardo Ribeiro Dos Santos, David C Spray, Herbert B Tanowitz

Affiliations

  1. Instituto Nacional de Cardiologia, 22240-006 Rio de Janeiro, RJ, Brazil.

PMID: 19547703 PMCID: PMC2696023 DOI: 10.1155/2009/484358

Abstract

Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In these individuals heart transplantation has been attempted. However, this procedure is fraught with many problems attributable to the surgery and the postsurgical administration of immunosuppressive drugs. Studies in mice suggest that the transplantation of bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection. Cardiac magnetic resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement. On the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic end-stage heart disease. The initial results are encouraging and more studies need to be performed.

References

  1. Circulation. 2002 Jan 1;105(1):93-8 - PubMed
  2. Nature. 2001 Apr 5;410(6829):701-5 - PubMed
  3. Ann N Y Acad Sci. 1995 Mar 27;752:446-54 - PubMed
  4. Arq Bras Cardiol. 1960 Sep;13:236-43 - PubMed
  5. Nat Med. 2004 May;10(5):494-501 - PubMed
  6. Nat Med. 2001 Apr;7(4):430-6 - PubMed
  7. Circulation. 2006 Jul 4;114(1 Suppl):I120-4 - PubMed
  8. Int J Cardiol. 2005 Jul 10;102(2):239-47 - PubMed
  9. Am J Pathol. 2004 Feb;164(2):441-7 - PubMed
  10. Circulation. 1999 Nov 9;100(19 Suppl):II247-56 - PubMed
  11. Nat Med. 2005 Mar;11(3):305-11 - PubMed
  12. Nat Med. 2005 Apr;11(4):367-8 - PubMed
  13. Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H464-70 - PubMed
  14. Rev Inst Med Trop Sao Paulo. 1963 Sep-Oct;5:236-42 - PubMed
  15. Prog Cardiovasc Dis. 1964 Nov;7:199-225 - PubMed
  16. Ann Thorac Surg. 2001 Jun;71(6):1833-8 - PubMed
  17. Nature. 2004 Apr 8;428(6983):668-73 - PubMed
  18. Am Heart J. 1955 Oct;50(4):492-527 - PubMed
  19. Arq Bras Cardiol. 2007 Aug;89(2):e10-1 - PubMed
  20. Trials. 2007 Jan 18;8:2 - PubMed
  21. J Clin Invest. 1999 Mar;103(5):697-705 - PubMed
  22. Trends Parasitol. 2005 Nov;21(11):513-6 - PubMed
  23. Ann N Y Acad Sci. 2001 Jun;938:221-9; discussion 229-30 - PubMed
  24. J Infect Dis. 2008 Feb 15;197(4):544-7 - PubMed
  25. Arq Bras Med. 1955 Jul-Aug;45(7-8):279-88 - PubMed
  26. Nat Med. 2003 Sep;9(9):1195-201 - PubMed
  27. Arq Bras Cardiol. 2006 Aug;87(2):159-66 - PubMed
  28. Nature. 2004 Apr 8;428(6983):664-8 - PubMed

Publication Types

Grant support