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Edwards CL, Raynor RD, Feliu M, et al. Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD). Neuropsychiatr Dis Treat. 2007;3(6):705-9doi: 10.2147/ndt.s518.
Edwards, C. L., Raynor, R. D., Feliu, M., McDougald, C., Johnson, S., Schmechel, D., Wood, M., Bennett, G. G., Saurona, P., Bonner, M., Wellington, C., DeCastro, L. M., Whitworth, E., Abrams, M., Logue, P., Edwards, L., Martinez, S., & Whitfield, K. E. (2007). Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD). Neuropsychiatric disease and treatment, 3(6), 705-9. https://doi.org/10.2147/ndt.s518
Edwards, Christopher L, et al. "Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD)." Neuropsychiatric disease and treatment vol. 3,6 (2007): 705-9. doi: https://doi.org/10.2147/ndt.s518
Edwards CL, Raynor RD, Feliu M, McDougald C, Johnson S, Schmechel D, Wood M, Bennett GG, Saurona P, Bonner M, Wellington C, DeCastro LM, Whitworth E, Abrams M, Logue P, Edwards L, Martinez S, Whitfield KE. Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD). Neuropsychiatr Dis Treat. 2007 Dec;3(6):705-9. doi: 10.2147/ndt.s518. PMID: 19300604; PMCID: PMC2656311.
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Neuropsychiatr Dis Treat. 2007 Dec;3(6):705-9. doi: 10.2147/ndt.s518.

Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD).

Neuropsychiatric disease and treatment

Christopher L Edwards, Renee Dunn Raynor, Miriam Feliu, Camela McDougald, Stephanie Johnson, Donald Schmechel, Mary Wood, Gary G Bennett, Patrick Saurona, Melanie Bonner, Chante' Wellington, Laura M DeCastro, Elaine Whitworth, Mary Abrams, Patrick Logue, Lekisha Edwards, Salutario Martinez, Keith E Whitfield

Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. [email protected]

PMID: 19300604 PMCID: PMC2656311 DOI: 10.2147/ndt.s518

Abstract

Traditionally, neuropsychological deficits due to Sickle Cell Disease (SCD) have been understudied in adults. We have begun to suspect, however, that symptomatic and asymptomatic Cerebrovascular Events (CVE) may account for an alarming number of deficits in this population. In the current brief review, we critically evaluated the pediatric and adult literatures on the neurocognitive effects of SCD. We highlighted the studies that have been published on this topic and posit that early detection of CVE via neurocognitive testing, neuropsychiatric evaluations, and neuroimaging may significantly reduce adult cognitive and functional morbidities.

Keywords: cerebral vascular event; neuroimaging; neuropsychological assessment; sickle cell disease

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