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Opt Express. 2000 Jul 17;7(2):95-106. doi: 10.1364/oe.7.000095.

Multiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration.

Optics express

A Elsner, M Miura, S Burns, E Beausencourt, C Kunze, L Kelley, J Walker, G Wing, P Raskauskas, D Fletcher, Q Zhou, A Dreher

PMID: 19404374 DOI: 10.1364/oe.7.000095

Abstract

A novel technique, Multiply Scattered Light Tomography (MSLT), and confocal Infrared Imaging are used to provide diagnostic information using a comfortable, rapid, and noninvasive method. We investigated these techniques in detecting neovascularization in age-related macular degeneration. The MSLT used a Vertical Cavity Surface Emitting Laser (VCSEL) at 850 nm, while the confocal imaging technique used either the VCSEL or a 790 nm laser diode. Both were implemented into the topographical scanning system (TopSS, Laser Diagnostic Technologies, Inc.) Confocal imaging with both lasers provided different information about neovascularization as a function of focal plane, and different also from MSLT.

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