Display options
Cite
Korkmaz H, Onalan O, Akbulut M, et al. Nebivolol and quinapril reduce p-wave duration and dispersion in hypertensive patients. Indian Pacing Electrophysiol J. 2009;9(3):158-66
Korkmaz, H., Onalan, O., Akbulut, M., & Ozbay, Y. (2009). Nebivolol and quinapril reduce p-wave duration and dispersion in hypertensive patients. Indian pacing and electrophysiology journal, 9(3), 158-66.
Korkmaz, Hasan, et al. "Nebivolol and quinapril reduce p-wave duration and dispersion in hypertensive patients." Indian pacing and electrophysiology journal vol. 9,3 (2009): 158-66.
Korkmaz H, Onalan O, Akbulut M, Ozbay Y. Nebivolol and quinapril reduce p-wave duration and dispersion in hypertensive patients. Indian Pacing Electrophysiol J. 2009 May 15;9(3):158-66. PMID: 19471593; PMCID: PMC2683636.
Copy Download .nbib Format: NLM
Share it on

Indian Pacing Electrophysiol J. 2009 May 15;9(3):158-66.

Nebivolol and quinapril reduce p-wave duration and dispersion in hypertensive patients.

Indian pacing and electrophysiology journal

Hasan Korkmaz, Orhan Onalan, Mehmet Akbulut, Yilmaz Ozbay

Affiliations

  1. Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey. [email protected]

PMID: 19471593 PMCID: PMC2683636

Abstract

We aimed to investigate the effects of nebivolol and quinapril treatments on P-wave duration and dispersion in hypertensive patients. Hypertensive patients who were in sinus rhythm were assigned to the two treatment groups and received either 20 mg quinapril/day or 5 mg nebivolol/day. P-Wave dispersion (PWD) was measured at baseline and after four weeks of treatment and defined as the difference between the maximum (Pmax) and the minimum (Pmin) P-wave duration. The study group consisted of 54 patients (Mean age: 53 +/- 9 years, 46% women) with 27 patients in each group. At 4-week follow up both treatment groups showed a significant reduction (p< 0.001) in systolic (SBP) and diastolic blood pressure (DBP). Heart rate (HR) reduction was significant in patients receiving nebivolol (P=0.001). Both groups showed a similar (P=0.413 for PWD, p=0.651 for Pmax) but significant reduction in PWD (nebivolol: -16+/- 14, P< 0.0001 and quinapril: -13+/- 11, P< 0.0001) and Pmax (nebivolol: -10+/- 11, P=0.001 and quinapril: -9+/- 11, P=0.001). A 2 (Time) x 2 (Group) mixed-model repeated-measures analysis of variance revealed that the main effect of Time was significant for Pmax (P=0.002) and PWD (P=0.008) after controlling for changes in SBP, DBP and HR. However, the main effect of Group and Time x Group interaction was not significant for both variables (All p values > 0.05). In conclusion, short-term treatment with nebivolol and quinapril produces a similar but significant reduction in Pmax and PWD in hypertensive patients. This effect is independent of blood pressure and heart rate changes.

Keywords: Hypertension; Nebivolol; P-wave duration; Quinapril

References

  1. Circulation. 1999 Jul 6;100(1):87-95 - PubMed
  2. J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S23-9 - PubMed
  3. Cardiovasc Res. 2001 Feb 1;49(2):430-9 - PubMed
  4. Eur Heart J. 2007 Feb;28(4):457-62 - PubMed
  5. Am J Cardiol. 2000 Apr 1;85(7):896-9, A10 - PubMed
  6. Curr Cardiol Rep. 2005 Sep;7(5):382-90 - PubMed
  7. Eur Heart J. 1999 Feb;20(3):211-20 - PubMed
  8. J Am Coll Cardiol. 2000 Jul;36(1):139-46 - PubMed
  9. J Hypertens. 2007 Jan;25(1):15-23 - PubMed
  10. Int J Cardiol. 2005 Aug 3;103(1):37-40 - PubMed
  11. Circulation. 2000 Jun 6;101(22):2612-7 - PubMed
  12. Circulation. 2003 Aug 12;108(6):668-71 - PubMed
  13. Eur Heart J. 2006 Mar;27(5):512-8 - PubMed
  14. Clin Cardiol. 2001 Sep;24(9):597-602 - PubMed
  15. J Hum Hypertens. 2007 Jan;21(1):20-7 - PubMed
  16. J Am Coll Cardiol. 2007 Nov 20;50(21):2021-8 - PubMed
  17. Eur Heart J. 1994 Apr;15 Suppl A:9-16 - PubMed
  18. J Am Coll Cardiol. 1995 Aug;26(2):497-502 - PubMed
  19. Am J Ther. 2008 Jan-Feb;15(1):36-43 - PubMed
  20. J Electrocardiol. 2005 Jul;38(3):271-8 - PubMed
  21. J Hypertens. 2003 Jun;21(6):1011-53 - PubMed
  22. J Cardiovasc Pharmacol. 2000 Jun;35(6):845-8 - PubMed
  23. Int J Cardiovasc Imaging. 2007 Oct;23(5):549-55 - PubMed
  24. Ann Noninvasive Electrocardiol. 2001 Apr;6(2):159-65 - PubMed
  25. J Clin Pharmacol. 2008 Feb;48(2):225-39 - PubMed
  26. Europace. 2004 Jul;6(4):343-50 - PubMed
  27. Circulation. 2003 Apr 15;107(14):1930-6 - PubMed
  28. Am Heart J. 2000 May;139(5):814-9 - PubMed
  29. Am J Cardiol. 1986 Feb 15;57(6):450-8 - PubMed
  30. Physiol Rev. 2006 Jul;86(3):747-803 - PubMed
  31. Cardiovasc Res. 2002 May;54(2):390-6 - PubMed
  32. Pacing Clin Electrophysiol. 2000 Mar;23(3):352-8 - PubMed

Publication Types