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Umlauf J, Horký M. Molecular biology of doxorubicin-induced cardiomyopathy. Exp Clin Cardiol. 2002;7(1):35-9
Umlauf, J., & Horký, M. (2002). Molecular biology of doxorubicin-induced cardiomyopathy. Experimental and clinical cardiology, 7(1), 35-9.
Umlauf, J, and Horký, M. "Molecular biology of doxorubicin-induced cardiomyopathy." Experimental and clinical cardiology vol. 7,1 (2002): 35-9.
Umlauf J, Horký M. Molecular biology of doxorubicin-induced cardiomyopathy. Exp Clin Cardiol. 2002;7(1):35-9. PMID: 19644577; PMCID: PMC2716188.
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Exp Clin Cardiol. 2002;7(1):35-9.

Molecular biology of doxorubicin-induced cardiomyopathy.

Experimental and clinical cardiology

J Umlauf, M Horký

Affiliations

  1. Masaryk Memorial Cancer Institute and.

PMID: 19644577 PMCID: PMC2716188

Abstract

The anthracycline doxorubicin is an antineoplastic agent, eliciting chronic cardiac toxicity. It occurs in patients after prolonged administration of doxorubicin, leading to congestive heart failure. The pathogenesis of the doxorubicin-induced car-diomyopathy is not well understood. The present article summarizes the unique effect of doxorubicin on cardiac-specific gene expression. In addition to binding to DNA, doxorubicin directly affects the function of a variety of proteins. Free radical generation, damage to mitochondria and active cell death are also critical in the development of doxorubicin-induced cardiac toxicity. Agents providing effective cardioprotection are also reviewed.

Keywords: Cardiomyopathy; Cardioprotection; DNA damage; Doxorubicin; Mitochondrial dysfunction

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