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Massé H, Guyomard JL, Baudet D, et al. Mitoxantrone therapy for acute posterior multifocal placoid pigment epitheliopathy with cerebral vasculitis. Case Rep Med. 2009;2009:481512doi: 10.1155/2009/481512.
Massé, H., Guyomard, J. L., Baudet, D., Pinel, J. F., Edan, G., & Charlin, J. F. (2009). Mitoxantrone therapy for acute posterior multifocal placoid pigment epitheliopathy with cerebral vasculitis. Case reports in medicine, 2009481512. https://doi.org/10.1155/2009/481512
Massé, Hélène, et al. "Mitoxantrone therapy for acute posterior multifocal placoid pigment epitheliopathy with cerebral vasculitis." Case reports in medicine vol. 2009 (2009): 481512. doi: https://doi.org/10.1155/2009/481512
Massé H, Guyomard JL, Baudet D, Pinel JF, Edan G, Charlin JF. Mitoxantrone therapy for acute posterior multifocal placoid pigment epitheliopathy with cerebral vasculitis. Case Rep Med. 2009;2009:481512. doi: 10.1155/2009/481512. Epub 2009 May 19. PMID: 19710935; PMCID: PMC2729475.
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Case Rep Med. 2009;2009:481512. doi: 10.1155/2009/481512. Epub 2009 May 19.

Mitoxantrone therapy for acute posterior multifocal placoid pigment epitheliopathy with cerebral vasculitis.

Case reports in medicine

Hélène Massé, Jean-Laurent Guyomard, Dominique Baudet, Jean-François Pinel, Gilles Edan, Jean-François Charlin

Affiliations

  1. Service d'ophtalmologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, France.

PMID: 19710935 PMCID: PMC2729475 DOI: 10.1155/2009/481512

Abstract

Purpose. To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone. Design. Single case report. Method. A 22-year-old man presented with acute isolated bilateral loss of vision revealing APMPPE. Corticosteroid therapy was initiated and visual acuity gradually improved. Seventeen days later, visual function deteriorated again, associated with flu-like syndrome and severe headaches. A relapse of APMPPE was diagnosed, complicated with lymphocytic meningitis and cerebral ischemia. Intravenous therapy with mitoxantrone was performed in combination with methylprednisolone. Results. Headaches disappeared in a few days whereas visual acuity gradually improved and stabilized at 20/40 in the right eye and 20/32 in the left eye. No adverse event was observed. Clinical improvement was confirmed by magnetic resonance imaging. Conclusion. Cerebral vasculitis is the most severe complication of the extraocular manifestations of APMPEE. This diagnosis should be evoked when severe headaches or behavior disorder are associated with APMPEE.

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