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Korhonen T, Kinnunen TH, Garvey AJ. Impact of Nicotine Replacement Therapy on post-cessation mood profile by pre-cessation depressive symptoms. Tob Induc Dis. 2006;3(2):17-33doi: 10.1186/1617-9625-3-2-17.
Korhonen, T., Kinnunen, T. H., & Garvey, A. J. (2006). Impact of Nicotine Replacement Therapy on post-cessation mood profile by pre-cessation depressive symptoms. Tobacco induced diseases, 3(2), 17-33. https://doi.org/10.1186/1617-9625-3-2-17
Korhonen, Tellervo, et al. "Impact of Nicotine Replacement Therapy on post-cessation mood profile by pre-cessation depressive symptoms." Tobacco induced diseases vol. 3,2 (2006): 17-33. doi: https://doi.org/10.1186/1617-9625-3-2-17
Korhonen T, Kinnunen TH, Garvey AJ. Impact of Nicotine Replacement Therapy on post-cessation mood profile by pre-cessation depressive symptoms. Tob Induc Dis. 2006 Aug 15;3(2):17-33. doi: 10.1186/1617-9625-3-2-17. PMID: 19570294; PMCID: PMC2633369.
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Tob Induc Dis. 2006 Aug 15;3(2):17-33. doi: 10.1186/1617-9625-3-2-17.

Impact of Nicotine Replacement Therapy on post-cessation mood profile by pre-cessation depressive symptoms.

Tobacco induced diseases

Tellervo Korhonen, Taru H Kinnunen, Arthur J Garvey

Affiliations

  1. Tobacco Dependence Treatment and Research, Harvard School of Dental Medicine, Boston, MA, USA.

PMID: 19570294 PMCID: PMC2633369 DOI: 10.1186/1617-9625-3-2-17

Abstract

We evaluated the effects of Nicotine Replacement Therapy (NRT) on the Profile of Mood States (POMS), testing whether pre-cessation depressive symptoms modify NRT's effects on POMS. Out of 608 smokers attempting to quit with NRT, this secondary analysis included 242 participants abstinent for at least two weeks. We measured pre-cessation depressive symptoms with the Center for Epidemiological Studies Depression Scale. At 1, 7, and 14 post-cessation days we examined 6 self-reported POMS, i.e. feeling 'anxious', 'sad', 'confused', 'angry', 'energetic' and 'fatigue'. The results of the ANCOVA models suggested no NRT effects on feeling anxious, energetic or fatigue. We found that pre-cessation depression modified NRT effects in some specific mood states, such as depression by NRT- interaction effects on feeling confused and feeling angry. On average, the depressed participants in the placebo groups had the highest symptom scores. However, those depressed in NRT conditions did not have significantly higher symptom scores compared to the non-depressed groups. In treating those negative moods NRT may be particularly important for persons with depressive symptoms before cessation.

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