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Exp Clin Cardiol. 2002;7(2):120-7.

Factors determining heterogeneity in coronary collateral development: A clinical perspective.

Experimental and clinical cardiology

Pier D Lambiase, Michael S Marber

Affiliations

  1. Department of Cardiology, Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London, United Kingdom.

PMID: 19649235 PMCID: PMC2719174

Abstract

The mechanisms responsible for collateral development have attracted considerable attention in cellular and molecular research because these vessels have the capacity to protect against myocardial infarction and reduce exercise-induced ischemia. This has led to a number of phase I trials employing angiogenic peptides, genes and cell transplantation. However, there are significant differences in the degree of collateral development among patients even with similar patterns of coronary disease. Understanding the factors responsible for this heterogeneity has important implications for the efficacy of future therapeutic strategies. Therefore, this review will examine these factors from the clinical perspective integrating the clinical evidence with recent molecular and cellular studies. The role of specific pharmacological agents and novel investigational strategies will be discussed.

Keywords: Angiogenesis; Coronary collaterals; Ischemia; Myocardial infarction

References

  1. Circulation. 2000 Dec 19;102(25):3098-103 - PubMed
  2. Circulation. 1997 Oct 21;96(8):2667-74 - PubMed
  3. Am J Physiol. 1982 Jun;242(6):H1031-7 - PubMed
  4. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4678-82 - PubMed
  5. Circulation. 1999 May 4;99(17):2239-42 - PubMed
  6. Circulation. 1989 Apr;79(4):791-6 - PubMed
  7. Circulation. 1999 Aug 3;100(5):547-52 - PubMed
  8. Circulation. 1999 Jun 15;99(23):3043-9 - PubMed
  9. Circulation. 2002 Jan 1;105(1):67-72 - PubMed
  10. Am J Cardiol. 1991 Dec 15;68(17):1593-9 - PubMed
  11. Am J Physiol. 1990 Apr;258(4 Pt 2):H1103-11 - PubMed
  12. Circulation. 1998 Dec 22-29;98(25):2800-4 - PubMed
  13. EMBO J. 1999 Jul 15;18(14):3964-72 - PubMed
  14. J Am Coll Cardiol. 1998 Jul;32(1):49-56 - PubMed
  15. Nat Med. 1999 Apr;5(4):434-8 - PubMed
  16. Circulation. 2000 May 30;101(21):2526-31 - PubMed
  17. Circulation. 2000 Oct 31;102(18):2255-61 - PubMed
  18. J Clin Invest. 1999 May;103(9):1231-6 - PubMed
  19. Circulation. 2000 Jul 11;102(2):185-90 - PubMed
  20. Circ Res. 1989 Feb;64(2):287-96 - PubMed
  21. Nature. 1999 Jun 10;399(6736):601-5 - PubMed
  22. Cardiovasc Res. 1990 Apr;24(4):271-7 - PubMed
  23. Blood Purif. 1995;13(3-4):112-24 - PubMed
  24. Science. 1997 Feb 14;275(5302):964-7 - PubMed
  25. J Clin Invest. 1998 Jan 1;101(1):40-50 - PubMed
  26. Cardiovasc Res. 1996 Apr;31(4):568-76 - PubMed
  27. Nat Med. 2000 Apr;6(4):389-95 - PubMed
  28. Blood. 2000 Feb 1;95(3):952-8 - PubMed
  29. Circ Res. 2000 Jan 7-21;86(1):4-5 - PubMed
  30. Circ Res. 2001 Jul 6;89(1):E1-7 - PubMed
  31. J Clin Invest. 1996 Aug 1;98(3):671-9 - PubMed
  32. Nat Med. 2000 Sep;6(9):1004-10 - PubMed
  33. Circ Res. 1997 Jun;80(6):845-52 - PubMed
  34. J Clin Invest. 1996 Jun 15;97(12):2736-44 - PubMed
  35. J Biol Chem. 1995 Dec 29;270(52):31189-95 - PubMed
  36. J Clin Invest. 1998 Jun 1;101(11):2567-78 - PubMed
  37. Circulation. 1996 May 1;93(9):1734-9 - PubMed
  38. Experientia. 1967 Jul 15;23(7):595-6 - PubMed
  39. Ann N Y Acad Sci. 2001 Jun;938:221-9; discussion 229-30 - PubMed
  40. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3422-7 - PubMed
  41. Circulation. 2001 Jun 19;103(24):2885-90 - PubMed
  42. J Biol Chem. 2000 Sep 22;275(38):29643-7 - PubMed
  43. Int J Cardiol. 1990 May;27(2):179-86 - PubMed
  44. Circulation. 1992 Mar;85(3):1197-204 - PubMed
  45. Circ Res. 1999 Aug 6;85(3):221-8 - PubMed
  46. J Am Coll Cardiol. 1998 Mar 1;31(3):512-8 - PubMed
  47. J Am Coll Cardiol. 1999 Oct;34(4):1005-11 - PubMed
  48. Circulation. 1996 Feb 1;93(3):544-51 - PubMed
  49. Circulation. 1999 Jan 5-12;99(1):111-20 - PubMed
  50. Circulation. 1999 Nov 9;100(19):1945-50 - PubMed
  51. Am J Physiol. 1996 Apr;270(4 Pt 2):H1462-8 - PubMed
  52. Circulation. 1999 Aug 3;100(5):468-74 - PubMed
  53. Curr Opin Genet Dev. 1998 Oct;8(5):588-94 - PubMed
  54. Circ Res. 2000 Jun 23;86(12):1198-202 - PubMed
  55. Circulation. 1995 Aug 15;92(4):950-61 - PubMed
  56. FASEB J. 2000 May;14(7):871-6 - PubMed
  57. Circulation. 1998 Jan 6-13;97(1):99-107 - PubMed
  58. Am J Physiol. 1998 Oct;275(4):H1411-8 - PubMed
  59. J Clin Invest. 1987 Jan;79(1):170-4 - PubMed
  60. J Clin Invest. 2001 Aug;108(3):399-405 - PubMed
  61. Circulation. 1991 Mar;83(3):739-46 - PubMed
  62. Circulation. 2000 Jan 18;101(2):207-13 - PubMed
  63. Circulation. 1982 Jan;65(1):40-8 - PubMed
  64. Circulation. 1996 Oct 1;94(7):1647-54 - PubMed
  65. Circ Res. 1971 Jun;28(6):671-9 - PubMed
  66. Ann Thorac Surg. 1999 Sep;68(3):830-6; discussion 836-7 - PubMed
  67. J Clin Invest. 1996 Jan 15;97(2):469-76 - PubMed

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