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Larsen EK, Nielsen T, Wittenborn T, et al. Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors. ACS Nano. 2009;3(7):1947-51doi: 10.1021/nn900330m.
Larsen, E. K., Nielsen, T., Wittenborn, T., Birkedal, H., Vorup-Jensen, T., Jakobsen, M. H., Ostergaard, L., Horsman, M. R., Besenbacher, F., Howard, K. A., & Kjems, J. (2009). Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors. ACS nano, 3(7), 1947-51. https://doi.org/10.1021/nn900330m
Larsen, Esben K U, et al. "Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors." ACS nano vol. 3,7 (2009): 1947-51. doi: https://doi.org/10.1021/nn900330m
Larsen EK, Nielsen T, Wittenborn T, Birkedal H, Vorup-Jensen T, Jakobsen MH, Ostergaard L, Horsman MR, Besenbacher F, Howard KA, Kjems J. Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors. ACS Nano. 2009 Jul 28;3(7):1947-51. doi: 10.1021/nn900330m. Epub 2009 Jul 02. PMID: 19572620.
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ACS Nano. 2009 Jul 28;3(7):1947-51. doi: 10.1021/nn900330m. Epub 2009 Jul 02.

Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.

ACS nano

Esben K U Larsen, Thomas Nielsen, Thomas Wittenborn, Henrik Birkedal, Thomas Vorup-Jensen, Mogens H Jakobsen, Leif Ostergaard, Michael R Horsman, Flemming Besenbacher, Kenneth A Howard, Jørgen Kjems

Affiliations

  1. Interdisciplinary Nanoscience Center (iNANO), Departments of Molecular Biology, Physics and Astronomy, Chemistry, and Medical Microbiology & Immunology, Aarhus University, DK-8000 Aarhus C, Denmark.

PMID: 19572620 DOI: 10.1021/nn900330m

Abstract

Magnetic nanoparticles (MNP) can be used as contrast-enhancing agents to visualize tumors by magnetic resonance imaging (MRI). Here we describe an easy synthesis method of magnetic nanoparticles coated with polyethylene glycol (PEG) and demonstrate size-dependent accumulation in murine tumors following intravenous injection. Biocompatible iron oxide MNPs coated with PEG were prepared by replacing oleic acid with a biocompatible and commercially available silane-PEG to provide an easy and effective method for chemical coating. The colloidal stable PEGylated MNPs were magnetically separated into two distinct size subpopulations of 20 and 40 nm mean diameters with increased phagocytic uptake observed for the 40 nm size range in vitro. MRI detection revealed greater iron accumulation in murine tumors for 40 nm nanoparticles after intravenous injection. The enhanced MRI contrast of the larger MNPs in the tumor may be a combined result of the size-dependent extravasation and capture by macrophages in the tumor, providing important considerations for improved bioimaging approaches.

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