Display options
Cite
Schulze-Bonhage A. Deep brain stimulation: a new approach to the treatment of epilepsy. Dtsch Arztebl Int. 2009;106(24):407-12doi: 10.3238/arztebl.2009.0407.
Schulze-Bonhage, A. (2009). Deep brain stimulation: a new approach to the treatment of epilepsy. Deutsches Arzteblatt international, 106(24), 407-12. https://doi.org/10.3238/arztebl.2009.0407
Schulze-Bonhage, Andreas. "Deep brain stimulation: a new approach to the treatment of epilepsy." Deutsches Arzteblatt international vol. 106,24 (2009): 407-12. doi: https://doi.org/10.3238/arztebl.2009.0407
Schulze-Bonhage A. Deep brain stimulation: a new approach to the treatment of epilepsy. Dtsch Arztebl Int. 2009 Jun;106(24):407-12. doi: 10.3238/arztebl.2009.0407. Epub 2009 Jun 12. PMID: 19623308; PMCID: PMC2704363.
Copy Download .nbib Format: NLM
Share it on

Dtsch Arztebl Int. 2009 Jun;106(24):407-12. doi: 10.3238/arztebl.2009.0407. Epub 2009 Jun 12.

Deep brain stimulation: a new approach to the treatment of epilepsy.

Deutsches Arzteblatt international

Andreas Schulze-Bonhage

Affiliations

  1. Epilepsiezentrum am Universitätsklinikum Freiburg, 79106 Freiburg, Germany. [email protected]

PMID: 19623308 PMCID: PMC2704363 DOI: 10.3238/arztebl.2009.0407

Abstract

BACKGROUND: Deep brain stimulation, known to be effective in the treatment of movement disorders, is now attracting increasing interest in the treatment of other neurological and psychiatric diseases, particularly pain syndromes and epilepsy. It may be a new treatment option for intractable epilepsy.

METHODS: Selective literature review of human applications of deep brain stimulation in epilepsy presented together with the author's own experimental and clinical experience.

RESULTS: Conceptually, deep brain stimulation might be used to prevent the spread of epileptic discharges or to suppress their generation. Various target structures in the brain, including the thalamus, the subthalamic nucleus, and foci in the hippocampus and neocortex, are currently of interest and are being analyzed in multicenter clinical studies. In parallel, experimental models of epilepsy are being used to help determine the suitable stimulation parameters, e.g., frequency or type of stimulation. Recent clinical studies on stimulation of epileptic foci indicate a favorable ratio of efficacy to adverse effects in the treatment of temporal lobe epilepsy, although only a small number of patients have been so treated to date.

CONCLUSIONS: Large-scale studies involving stimulation of the thalamus and of cortical foci are now underway in the United States. On the basis of the favorable results of focus stimulation, a multicenter study in Europe is currently comparing the safety and efficacy of hippocampal stimulation to that of surgical treatments. These studies are expected to yield benchmark findings in the next few years that will determine the role deep brain stimulation will play in the treatment of epilepsy.

Keywords: cardiac surgery; coronary heart disease; efficacy; electrostimulation; epilepsy; health economics; life expectancy; surgery; treatment

References

  1. BMC Neurol. 2007 Mar 16;7:7 - PubMed
  2. Epilepsia. 2007 Aug;48(8):1543-50 - PubMed
  3. Neurology. 1995 Feb;45(2):224-30 - PubMed
  4. J Physiol. 2001 Feb 15;531(Pt 1):181-91 - PubMed
  5. Epilepsia. 2007 Oct;48(10):1895-903 - PubMed
  6. Stereotact Funct Neurosurg. 2001;77(1-4):223-7 - PubMed
  7. Epilepsia. 1992 Sep-Oct;33(5):841-51 - PubMed
  8. Stereotact Funct Neurosurg. 2005;83(4):153-8 - PubMed
  9. Stereotact Funct Neurosurg. 2001;77(1-4):228-32 - PubMed
  10. Prog Neurobiol. 1986;27(1):1-12 - PubMed
  11. Neurology. 2006 May 23;66(10):1571-3 - PubMed
  12. Epilepsia. 2004 Apr;45(4):346-54 - PubMed
  13. Brain. 2005 May;128(Pt 5):1188-98 - PubMed
  14. Mov Disord. 2007 Jul 30;22(10):1486-1489 - PubMed
  15. Neurosurgery. 1977 Sep-Oct;1(2):203-5 - PubMed
  16. J Clin Neurophysiol. 2001 Nov;18(6):514-32 - PubMed
  17. Epilepsia. 2007 Aug;48(8):1561-71 - PubMed
  18. Trans Am Neurol Assoc. 1973;98:192-6 - PubMed
  19. Epileptic Disord. 2002 Dec;4 Suppl 3:S83-93 - PubMed
  20. J Neurosurg. 1978 Mar;48(3):407-16 - PubMed
  21. Epilepsia. 2006 Jul;47(7):1203-12 - PubMed
  22. Epileptic Disord. 2005 Sep;7 Suppl 1:S22-6 - PubMed
  23. Epilepsia. 1990;31 Suppl 2:S27-32 - PubMed
  24. J Clin Neurophysiol. 2008 Jun;25(3):119-31 - PubMed
  25. Neurology. 2006 May 23;66(10):1490-4 - PubMed
  26. Neurotherapeutics. 2008 Jan;5(1):68-74 - PubMed
  27. Epilepsia. 2005 Jul;46(7):1071-81 - PubMed
  28. J Neurol Neurosurg Psychiatry. 2008 Jan;79(1):103-5 - PubMed
  29. Biol Cybern. 2003 Aug;89(2):81-8 - PubMed
  30. Epilepsia. 1998 Jul;39(7):709-14 - PubMed
  31. Epilepsia. 2002 Aug;43(8):836-46 - PubMed
  32. Neurology. 1999 Dec 10;53(9):2073-81 - PubMed
  33. Epilepsia. 2000 Feb;41(2):158-69 - PubMed
  34. Acta Neurochir Suppl (Wien). 1993;58:201-4 - PubMed
  35. Clin Neurol Neurosurg. 2004 Sep;106(4):318-29 - PubMed
  36. Neurology. 1998 Jul;51(1):48-55 - PubMed
  37. Neurobiol Dis. 2007 Sep;27(3):292-300 - PubMed
  38. Ann Neurol. 2005 Feb;57(2):258-68 - PubMed
  39. Acta Neurochir (Wien). 1976;(23 Suppl):257-62 - PubMed
  40. J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):769-74 - PubMed
  41. Epilepsy Res. 1998 Jun;31(1):39-46 - PubMed
  42. Epilepsia. 2007 Aug;48(8):1551-60 - PubMed
  43. Stereotact Funct Neurosurg. 1997;69(1-4 Pt 2):221-4 - PubMed
  44. Stereotact Funct Neurosurg. 1992;58(1-4):200-8 - PubMed
  45. Acta Neurochir Suppl. 2007;97(Pt 2):347-56 - PubMed
  46. J Neurosurg. 2006 Dec;105(6):894-7 - PubMed
  47. N Engl J Med. 2000 Feb 3;342(5):314-9 - PubMed

MeSH terms

Publication Types