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Delis SG, Bakoyiannis A, Biliatis I, et al. Model for end-stage liver disease (MELD) score, as a prognostic factor for post-operative morbidity and mortality in cirrhotic patients, undergoing hepatectomy for hepatocellular carcinoma. HPB (Oxford). 2009;11(4):351-7doi: 10.1111/j.1477-2574.2009.00067.x.
Delis, S. G., Bakoyiannis, A., Biliatis, I., Athanassiou, K., Tassopoulos, N., & Dervenis, C. (2009). Model for end-stage liver disease (MELD) score, as a prognostic factor for post-operative morbidity and mortality in cirrhotic patients, undergoing hepatectomy for hepatocellular carcinoma. HPB : the official journal of the International Hepato Pancreato Biliary Association, 11(4), 351-7. https://doi.org/10.1111/j.1477-2574.2009.00067.x
Delis, Spiros G, et al. "Model for end-stage liver disease (MELD) score, as a prognostic factor for post-operative morbidity and mortality in cirrhotic patients, undergoing hepatectomy for hepatocellular carcinoma." HPB : the official journal of the International Hepato Pancreato Biliary Association vol. 11,4 (2009): 351-7. doi: https://doi.org/10.1111/j.1477-2574.2009.00067.x
Delis SG, Bakoyiannis A, Biliatis I, Athanassiou K, Tassopoulos N, Dervenis C. Model for end-stage liver disease (MELD) score, as a prognostic factor for post-operative morbidity and mortality in cirrhotic patients, undergoing hepatectomy for hepatocellular carcinoma. HPB (Oxford). 2009 Jun;11(4):351-7. doi: 10.1111/j.1477-2574.2009.00067.x. PMID: 19718364; PMCID: PMC2727090.
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HPB (Oxford). 2009 Jun;11(4):351-7. doi: 10.1111/j.1477-2574.2009.00067.x.

Model for end-stage liver disease (MELD) score, as a prognostic factor for post-operative morbidity and mortality in cirrhotic patients, undergoing hepatectomy for hepatocellular carcinoma.

HPB : the official journal of the International Hepato Pancreato Biliary Association

Spiros G Delis, Andreas Bakoyiannis, Ioannis Biliatis, Konstantinos Athanassiou, Nikos Tassopoulos, Christos Dervenis

Affiliations

  1. Division of Liver and GI Transplantation, University of Miami Miller School of Medicine, Miami, FL, USA. [email protected]

PMID: 19718364 PMCID: PMC2727090 DOI: 10.1111/j.1477-2574.2009.00067.x

Abstract

BACKGROUND/AIMS: To evaluate the ability of the model for end-stage liver disease (MELD) in predicting the post-hepatectomy outcome for hepatocellular carcinoma (HCC).

METHODS: Between 2001 and 2004, 69 cirrhotic patients with HCC underwent hepatectomy and the results were retrospectively analysed. MELD score was associated with post-operative mortality and morbidity, hospital stay and 3-year survival.

RESULTS: Seventeen major and 52 minor resections were performed. Thirty-day mortality rate was 7.2%. MELD < or = 9 was associated with no peri-operative mortality vs. 19% when MELD > 9 (P < 0.02). Overall morbidity rate was 36.23%; 48% when MELD > 9 vs. 25% when MELD < or = 9 (P < 0.02). Median hospital stay was 12 days [8.8 days, when MELD < or = 9 and 15.6 days when MELD > 9 (P = 0.037)]. Three-year survival reached 49% (66% when MELD < or = 9; 32% when MELD > 9 (P < 0.01). In multivariate analysis, MELD > 9 (P < 0.01), clinical tumour symptoms (P < 0.05) and American Society of Anesthesiologists (ASA) score (P < 0.05) were independent predictors of peri-operative mortality; MELD > 9 (P < 0.01), tumour size >5 cm (P < 0.01), high tumour grade (P = 0.01) and absence of tumour capsule (P < 0.01) were independent predictors of decreased long-term survival.

CONCLUSION: MELD score seems to predict outcome of cirrhotic patients with HCC, after hepatectomy.

Keywords: MELD score; cirrhosis; hepatectomy; hepatocellular carcinoma; liver resection outcome

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