Display options
Cite
Park JA, Kim EK, Kang HJ, et al. Initial response to treatment was highly associated with the prognosis of childhood rhabdomyosarcoma: a retrospective analysis of a single center experience in Korea. Cancer Res Treat. 2008;40(3):111-5doi: 10.4143/crt.2008.40.3.111.
Park, J. A., Kim, E. K., Kang, H. J., Shin, H. Y., Kim, I. H., & Ahn, H. S. (2008). Initial response to treatment was highly associated with the prognosis of childhood rhabdomyosarcoma: a retrospective analysis of a single center experience in Korea. Cancer research and treatment, 40(3), 111-5. https://doi.org/10.4143/crt.2008.40.3.111
Park, Jeong A, et al. "Initial response to treatment was highly associated with the prognosis of childhood rhabdomyosarcoma: a retrospective analysis of a single center experience in Korea." Cancer research and treatment vol. 40,3 (2008): 111-5. doi: https://doi.org/10.4143/crt.2008.40.3.111
Park JA, Kim EK, Kang HJ, Shin HY, Kim IH, Ahn HS. Initial response to treatment was highly associated with the prognosis of childhood rhabdomyosarcoma: a retrospective analysis of a single center experience in Korea. Cancer Res Treat. 2008 Sep;40(3):111-5. doi: 10.4143/crt.2008.40.3.111. Epub 2008 Sep 30. PMID: 19688116; PMCID: PMC2697467.
Copy Download .nbib Format: NLM
Share it on

Cancer Res Treat. 2008 Sep;40(3):111-5. doi: 10.4143/crt.2008.40.3.111. Epub 2008 Sep 30.

Initial response to treatment was highly associated with the prognosis of childhood rhabdomyosarcoma: a retrospective analysis of a single center experience in Korea.

Cancer research and treatment

Jeong A Park, Eun Kyung Kim, Hyoung Jin Kang, Hee Young Shin, Il Han Kim, Hyo Seop Ahn

Affiliations

  1. Department of Pediatrics and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

PMID: 19688116 PMCID: PMC2697467 DOI: 10.4143/crt.2008.40.3.111

Abstract

PURPOSE: Following the introduction of a multimodal approach to diagnosis and treatment, the prognosis of rhabdomyosarcoma (RMS) has markedly improved over the last three decades. However, there are few data on treatment outcomes in Korean patients.

MATERIALS AND METHODS: We performed a retrospective analysis of 77 patients with RMS diagnosed and treated at Seoul National University Children's Hospital between 1986 and 2005.

RESULTS: The overall 5-year survival and event-free survival rates for all patients were 77% and 59%, respectively. The Intergroup Rhabdomyosarcoma Study clinical grouping and initial response to treatment (20-week response) were important prognostic factors.

CONCLUSIONS: The outcome of childhood RMS was closely associated with the initial staging and the initial response to treatment. Modulating therapies according to initial responses and risk factors is critical, and new treatment strategies for high-risk patients are needed.

Keywords: Child; Korea; Prognosis; Rhabdomyosarcoma

References

  1. J Clin Oncol. 1995 Mar;13(3):610-30 - PubMed
  2. J Clin Oncol. 2007 Nov 1;25(31):4909-13 - PubMed
  3. J Clin Oncol. 1999 Dec;17(12):3706-19 - PubMed
  4. Bone Marrow Transplant. 1997 Feb;19(3):227-31 - PubMed
  5. Pediatr Blood Cancer. 2004 Jan;42(1):64-73 - PubMed
  6. Br J Cancer. 1977 Jan;35(1):1-39 - PubMed
  7. Cancer. 2005 Apr 1;103(7):1475-83 - PubMed
  8. N Engl J Med. 1991 Feb 14;324(7):461-71 - PubMed
  9. Cancer. 1994 Jan 1;73(1):109-17 - PubMed
  10. J Clin Oncol. 2004 Dec 1;22(23):4787-94 - PubMed
  11. Cell Death Differ. 2003 Jun;10(6):729-39 - PubMed
  12. Eur J Cancer. 2008 Apr;44(6):876-84 - PubMed
  13. J Clin Oncol. 2004 May 15;22(10):1902-8 - PubMed
  14. J Pediatr Hematol Oncol. 1995 Aug;17(3):265-9 - PubMed
  15. J Clin Oncol. 2000 Nov 1;18(21):3643-50 - PubMed
  16. Cancer. 1988 Jan 15;61(2):209-20 - PubMed
  17. Bone Marrow Transplant. 2000 Sep;26(6):627-32 - PubMed
  18. J Clin Oncol. 1999 Sep;17(9):2796-803 - PubMed

Publication Types