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Chai X, Förster E, Zhao S, et al. Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Commun Integr Biol. 2009;2(4):375-7doi: 10.4161/cib.2.4.8614.
Chai, X., Förster, E., Zhao, S., Bock, H. H., & Frotscher, M. (2009). Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Communicative & integrative biology, 2(4), 375-7. https://doi.org/10.4161/cib.2.4.8614
Chai, Xuejun, et al. "Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge." Communicative & integrative biology vol. 2,4 (2009): 375-7. doi: https://doi.org/10.4161/cib.2.4.8614
Chai X, Förster E, Zhao S, Bock HH, Frotscher M. Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Commun Integr Biol. 2009 Jul;2(4):375-7. doi: 10.4161/cib.2.4.8614. PMID: 19721896; PMCID: PMC2734053.
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Commun Integr Biol. 2009 Jul;2(4):375-7. doi: 10.4161/cib.2.4.8614.

Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge.

Communicative & integrative biology

Xuejun Chai, Eckart Förster, Shanting Zhao, Hans H Bock, Michael Frotscher

Affiliations

  1. Institut für Anatomie und Zellbiologie; Albert-Ludwigs-Universität Freiburg; Freiburg, Germany.

PMID: 19721896 PMCID: PMC2734053 DOI: 10.4161/cib.2.4.8614

Abstract

The extracellular matrix protein Reelin, secreted by Cajal-Retzius (CR) cells in the marginal zone (MZ) of the cerebral cortex, is important for neuronal migration during development. Two lipoprotein receptors for Reelin have been identified, apolipoprotein E receptor 2 (ApoER2) and the very low-density lipoprotein receptor (VLDLR). The binding of Reelin to these receptors induces tyrosine phosphorylation of an adapter protein, disabled 1 (Dab1) by src family kinases (SFKs). In the Reelin-deficient mutant reeler, cortical lamination is inverted with many neurons invading the marginal zone and others that are unable to migrate to their destinations and accumulate underneath their predecessors, suggesting a role for Reelin signaling in dynamic cytoskeletal reorganization. At present these effects of Reelin are poorly understood. In our recent study, we showed that Reelin induces serine3 phosphorylation of n-cofilin, an actin-depolymerizing protein promoting the disassembly of F-actin. Phosphorylation of cofilin renders it unable to depolymerize F-actin, thus stabilizing the cytoskeleton. We provided evidence for ApoER2, Dab1, SFKs and phosphatidylinositol-3-kinase (PI3K) to be involved in Reelin-induced cofilin phosphorylation. We found that phosphorylation of cofilin occurs in the leading processes of radially migrating neurons as they grow towards the Reelin-containing marginal zone. By cofilin phosphorylation, Reelin may act as a stop signal for radially migrating neurons.

Keywords: Reelin signaling; actin cytoskeleton; cofilin phosphorylation; radial migration; reeler mutant; stop signal

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