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Cruceanu C, Alda M, Turecki G. Lithium: a key to the genetics of bipolar disorder. Genome Med. 2009;1(8):79doi: 10.1186/gm79.
Cruceanu, C., Alda, M., & Turecki, G. (2009). Lithium: a key to the genetics of bipolar disorder. Genome medicine, 1(8), 79. https://doi.org/10.1186/gm79
Cruceanu, Cristiana, et al. "Lithium: a key to the genetics of bipolar disorder." Genome medicine vol. 1,8 (2009): 79. doi: https://doi.org/10.1186/gm79
Cruceanu C, Alda M, Turecki G. Lithium: a key to the genetics of bipolar disorder. Genome Med. 2009 Aug 19;1(8):79. doi: 10.1186/gm79. PMID: 19691823; PMCID: PMC2768965.
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Genome Med. 2009 Aug 19;1(8):79. doi: 10.1186/gm79.

Lithium: a key to the genetics of bipolar disorder.

Genome medicine

Cristiana Cruceanu, Martin Alda, Gustavo Turecki

Affiliations

  1. McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec H4H 1R3, Canada.

PMID: 19691823 PMCID: PMC2768965 DOI: 10.1186/gm79

Abstract

Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and phenotypically heterogeneous, but evidence suggests that individuals who respond well to lithium treatment have more homogeneous clinical and molecular profiles. Response to lithium seems to cluster in families and can be used as a predictor for recurrence of BD symptoms. While molecular studies have provided important information about possible genes involved in BD predisposition or in lithium response, neither the mechanism of action of this drug nor the genetic profile of bipolar disorder is, as yet, completely understood.

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