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Mogilevskaya E, Bagrova N, Plyusnina T, et al. Kinetic modeling as a tool to integrate multilevel dynamic experimental data. Methods Mol Biol. 2009;563:197-218doi: 10.1007/978-1-60761-175-2_11.
Mogilevskaya, E., Bagrova, N., Plyusnina, T., Gizzatkulov, N., Metelkin, E., Goryacheva, E., Smirnov, S., Kosinsky, Y., Dorodnov, A., Peskov, K., Karelina, T., Goryanin, I., & Demin, O. (2009). Kinetic modeling as a tool to integrate multilevel dynamic experimental data. Methods in molecular biology (Clifton, N.J.), 563197-218. https://doi.org/10.1007/978-1-60761-175-2_11
Mogilevskaya, Ekaterina, et al. "Kinetic modeling as a tool to integrate multilevel dynamic experimental data." Methods in molecular biology (Clifton, N.J.) vol. 563 (2009): 197-218. doi: https://doi.org/10.1007/978-1-60761-175-2_11
Mogilevskaya E, Bagrova N, Plyusnina T, Gizzatkulov N, Metelkin E, Goryacheva E, Smirnov S, Kosinsky Y, Dorodnov A, Peskov K, Karelina T, Goryanin I, Demin O. Kinetic modeling as a tool to integrate multilevel dynamic experimental data. Methods Mol Biol. 2009;563:197-218. doi: 10.1007/978-1-60761-175-2_11. PMID: 19597787.
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Methods Mol Biol. 2009;563:197-218. doi: 10.1007/978-1-60761-175-2_11.

Kinetic modeling as a tool to integrate multilevel dynamic experimental data.

Methods in molecular biology (Clifton, N.J.)

Ekaterina Mogilevskaya, Natalia Bagrova, Tatiana Plyusnina, Nail Gizzatkulov, Eugeniy Metelkin, Ekaterina Goryacheva, Sergey Smirnov, Yuriy Kosinsky, Aleksander Dorodnov, Kirill Peskov, Tatiana Karelina, Igor Goryanin, Oleg Demin

Affiliations

  1. Institute for Systems Biology SPb, Moscow, Russia.

PMID: 19597787 DOI: 10.1007/978-1-60761-175-2_11

Abstract

The metabolic networks are the most well-studied biochemical systems, with an abundance of in vitro and in vivo data available for quantitative estimation of its kinetic parameters. In this chapter, we present our approach to developing mathematical description of metabolic pathways. The model-based integration of reaction kinetics and the utilization of different types of experimental data including temporal dependencies have been described in detail. Software package DBSolve7 which allows us to develop kinetic model of the biochemical system and integrate experimental data has been presented.

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