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Brkanac Z, Raskind WH, King BH. Pharmacology and genetics of autism: implications for diagnosis and treatment. Per Med. 2008;5(6):599-607doi: 10.2217/17410541.5.6.599.
Brkanac, Z., Raskind, W. H., & King, B. H. (2008). Pharmacology and genetics of autism: implications for diagnosis and treatment. Personalized medicine, 5(6), 599-607. https://doi.org/10.2217/17410541.5.6.599
Brkanac, Zoran, et al. "Pharmacology and genetics of autism: implications for diagnosis and treatment." Personalized medicine vol. 5,6 (2008): 599-607. doi: https://doi.org/10.2217/17410541.5.6.599
Brkanac Z, Raskind WH, King BH. Pharmacology and genetics of autism: implications for diagnosis and treatment. Per Med. 2008 Nov;5(6):599-607. doi: 10.2217/17410541.5.6.599. PMID: 19727434; PMCID: PMC2692174.
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Per Med. 2008 Nov;5(6):599-607. doi: 10.2217/17410541.5.6.599.

Pharmacology and genetics of autism: implications for diagnosis and treatment.

Personalized medicine

Zoran Brkanac, Wendy H Raskind, Bryan H King

Affiliations

  1. Department of Psychiatry and Behavioral Sciences and Seattle Children's Hospital, Box 35-6560, University of Washington, Seattle, WA 98195-6560, USA.

PMID: 19727434 PMCID: PMC2692174 DOI: 10.2217/17410541.5.6.599

Abstract

Autism has the highest estimated heritability (>90%) among behaviorally defined neuropsychiatric disorders. Rapidly advancing genomic technologies and large international collaborations have increased our understanding of the molecular genetic causes of autism. Pharmacogenomic approaches are currently being applied in two single-gene disorders, fragile X syndrome and Rett syndrome, which capture many aspects of the autistic phenotype. This review describes the current state of the genetics of autism and suggests how to extend pharmacological principles pioneered in fragile X and Rett to the broader group of patients with autism.

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