Display options
Cite
Jermacz I, Maj J, Morzycki JW, et al. GC-MS Analysis of beta-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues. Toxicol Mech Methods. 2008;18(6):469-471doi: 10.1080/15376510701623656.
Jermacz, I., Maj, J., Morzycki, J. W., & Wojtkielewicz, A. (2008). GC-MS Analysis of beta-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues. Toxicology mechanisms and methods, 18(6), 469-471. https://doi.org/10.1080/15376510701623656
Jermacz, I, et al. "GC-MS Analysis of beta-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues." Toxicology mechanisms and methods vol. 18,6 (2008): 469-471. doi: https://doi.org/10.1080/15376510701623656
Jermacz I, Maj J, Morzycki JW, Wojtkielewicz A. GC-MS Analysis of beta-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues. Toxicol Mech Methods. 2008 Jul;18(6):469-471. doi: 10.1080/15376510701623656. Epub 2008 Jun 23. PMID: 19696942; PMCID: PMC2728759.
Copy Download .nbib Format: NLM
Share it on

Toxicol Mech Methods. 2008 Jul;18(6):469-471. doi: 10.1080/15376510701623656. Epub 2008 Jun 23.

GC-MS Analysis of beta-Carotene Ethenolysis Products and their Synthesis as Potentially Active Vitamin A Analogues.

Toxicology mechanisms and methods

I Jermacz, J Maj, J W Morzycki, A Wojtkielewicz

Affiliations

  1. Institute of Chemistry, University of Bialystok, Al. Pilsudskiego 11/4, 15-443, Bialystok, Poland.

PMID: 19696942 PMCID: PMC2728759 DOI: 10.1080/15376510701623656

Abstract

beta-Carotene ethenolysis under promotion of well-defined ruthenium catalysts were examined as a novel method of synthesis of vitamin A derivatives. Efficient reaction was promoted by the second-generation Hoveyda catalyst. The products of ethenolysis in positions C15-C15', C11-C12, and C9-C10 were detected, but cleavage of the C11-C12 double bond predominated. Even better regioselectivity at this position was observed for cross-metathesis between beta-carotene and functionalized alkenes.

References

  1. Org Lett. 2003 May 29;5(11):2007-9 - PubMed
  2. Org Lett. 2007 Jan 4;9(1):5-8 - PubMed
  3. Angew Chem Int Ed Engl. 2003 Apr 29;42(17):1900-23 - PubMed
  4. Org Lett. 2003 Sep 18;5(19):3439-42 - PubMed
  5. Free Radic Biol Med. 2003 Dec 1;35(11):1480-90 - PubMed
  6. Org Lett. 2003 May 29;5(11):1855-8 - PubMed
  7. Lancet. 1995 Jan 7;345(8941):31-5 - PubMed

Publication Types