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Gibbs ME, Robertson S, Hambley J. Amino acid uptake required for long-term memory formation. Neurosci Lett. 1977;4(5):293-7doi: 10.1016/0304-3940(77)90195-1.
Gibbs, M. E., Robertson, S., & Hambley, J. (1977). Amino acid uptake required for long-term memory formation. Neuroscience letters, 4(5), 293-7. https://doi.org/10.1016/0304-3940(77)90195-1
Gibbs, M E, et al. "Amino acid uptake required for long-term memory formation." Neuroscience letters vol. 4,5 (1977): 293-7. doi: https://doi.org/10.1016/0304-3940(77)90195-1
Gibbs ME, Robertson S, Hambley J. Amino acid uptake required for long-term memory formation. Neurosci Lett. 1977 Apr;4(5):293-7. doi: 10.1016/0304-3940(77)90195-1. PMID: 19604961.
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Neurosci Lett. 1977 Apr;4(5):293-7. doi: 10.1016/0304-3940(77)90195-1.

Amino acid uptake required for long-term memory formation.

Neuroscience letters

M E Gibbs, S Robertson, J Hambley

Affiliations

  1. Department of Psychology, La Trobe University, Bundoora, Victoria 3083, Australia; Department of Behavioural Biology, Research School of Biological Sciences, Canberra 2600 Australia.

PMID: 19604961 DOI: 10.1016/0304-3940(77)90195-1

Abstract

alpha-Amino-iso-butyrate (AIB) inhibits long-term, protein synthesis-dependent memory formation by reducing labelled leucine uptake in vivo without affecting leucine incorporation into protein. Unlike the antibiotic cycloheximide, AIB does not block long-term memory formation through inhibition of protein synthesis per se. The behavioural effect of AIB is restricted to times of administration between 5 min before and 5 min after learning a single trial passive avoidance task by day-old chickens. It is concluded that (1) AIB competes with normal amino acids for uptake into cells, and (2) the uptake of amino acids for protein synthesis specific to long-term memory formation takes place in the first few minutes following learning.

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