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Mueller RA, Lundberg D, Frye GD, et al. Cerebellar cGMP varies with motor function and respiratory gas exchange. Neurosci Lett. 1978;10(1):89-93doi: 10.1016/0304-3940(78)90017-4.
Mueller, R. A., Lundberg, D., Frye, G. D., Mailman, R. B., & Breese, G. R. (1978). Cerebellar cGMP varies with motor function and respiratory gas exchange. Neuroscience letters, 10(1), 89-93. https://doi.org/10.1016/0304-3940(78)90017-4
Mueller, R A, et al. "Cerebellar cGMP varies with motor function and respiratory gas exchange." Neuroscience letters vol. 10,1 (1978): 89-93. doi: https://doi.org/10.1016/0304-3940(78)90017-4
Mueller RA, Lundberg D, Frye GD, Mailman RB, Breese GR. Cerebellar cGMP varies with motor function and respiratory gas exchange. Neurosci Lett. 1978 Nov;10(1):89-93. doi: 10.1016/0304-3940(78)90017-4. PMID: 19605262.
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Neurosci Lett. 1978 Nov;10(1):89-93. doi: 10.1016/0304-3940(78)90017-4.

Cerebellar cGMP varies with motor function and respiratory gas exchange.

Neuroscience letters

R A Mueller, D Lundberg, G D Frye, R B Mailman, G R Breese

Affiliations

  1. Department of Psychiatry, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA.

PMID: 19605262 DOI: 10.1016/0304-3940(78)90017-4

Abstract

Paralysis of rats with d-tubocurarine decreased cerebellar guanosine 3': 5'-cyclic monophosphate (cGMP) content to about one third of normal values when arterial oxygen and carbon dioxide were maintained at normal values. In addition, altering arterial carbon dioxide tensions in these paralyzed rats revealed that cerebellar cGMP was inversely related to arterial carbon dioxide tension, and that this relationship could be blunted by increasing arterial oxygen tension. It is possible that part of the decrease in cerebellar cGMP content by CNS depressants observed in several species in many laboratories may be simply secondary to the decreased motor function and/or respiratory depression produced.

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