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Barbui C, Saraceno B, Liberati A, et al. Low-dose neuroleptic therapy and relapse in schizophrenia: meta-analysis of randomized controlled trials. Eur Psychiatry. 1996;11(6):306-13doi: 10.1016/S0924-9338(96)89899-3.
Barbui, C., Saraceno, B., Liberati, A., & Garattini, S. (1996). Low-dose neuroleptic therapy and relapse in schizophrenia: meta-analysis of randomized controlled trials. European psychiatry : the journal of the Association of European Psychiatrists, 11(6), 306-13. https://doi.org/10.1016/S0924-9338(96)89899-3
Barbui, C, et al. "Low-dose neuroleptic therapy and relapse in schizophrenia: meta-analysis of randomized controlled trials." European psychiatry : the journal of the Association of European Psychiatrists vol. 11,6 (1996): 306-13. doi: https://doi.org/10.1016/S0924-9338(96)89899-3
Barbui C, Saraceno B, Liberati A, Garattini S. Low-dose neuroleptic therapy and relapse in schizophrenia: meta-analysis of randomized controlled trials. Eur Psychiatry. 1996;11(6):306-13. doi: 10.1016/S0924-9338(96)89899-3. PMID: 19698471.
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Eur Psychiatry. 1996;11(6):306-13. doi: 10.1016/S0924-9338(96)89899-3.

Low-dose neuroleptic therapy and relapse in schizophrenia: meta-analysis of randomized controlled trials.

European psychiatry : the journal of the Association of European Psychiatrists

C Barbui, B Saraceno, A Liberati, S Garattini

PMID: 19698471 DOI: 10.1016/S0924-9338(96)89899-3

Abstract

We assessed the relative efficacy and effectiveness of low-versus standard-dose neuroleptic therapy in reducing relapse rate in schizophrenic patients. Six long-term randomized controlled trials were retrieved through a MEDLINE search. A dose regimen between 50 and 100 mg equivalent of chlorpromazine, compared to a conventional one between 200 and 500 mg, was found to increase the likelihood of relapse in chronic schizophrenic patients. Differences, however, were statistically significant at 12 but not at 24 months of treatment.

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