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Stassen HH, Angst J, Delini-Stula A. Onset of action under antidepressant treatment. Eur Psychiatry. 1997;12(4):163-5doi: 10.1016/S0924-9338(97)89099-2.
Stassen, H. H., Angst, J., & Delini-Stula, A. (1997). Onset of action under antidepressant treatment. European psychiatry : the journal of the Association of European Psychiatrists, 12(4), 163-5. https://doi.org/10.1016/S0924-9338(97)89099-2
Stassen, H H, et al. "Onset of action under antidepressant treatment." European psychiatry : the journal of the Association of European Psychiatrists vol. 12,4 (1997): 163-5. doi: https://doi.org/10.1016/S0924-9338(97)89099-2
Stassen HH, Angst J, Delini-Stula A. Onset of action under antidepressant treatment. Eur Psychiatry. 1997;12(4):163-5. doi: 10.1016/S0924-9338(97)89099-2. PMID: 19698526.
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Eur Psychiatry. 1997;12(4):163-5. doi: 10.1016/S0924-9338(97)89099-2.

Onset of action under antidepressant treatment.

European psychiatry : the journal of the Association of European Psychiatrists

H H Stassen, J Angst, A Delini-Stula

PMID: 19698526 DOI: 10.1016/S0924-9338(97)89099-2

Abstract

The issues of timing in antidepressant treatment are of great theoretical and practical relevance, even more so since recent meta-analyses yielded no evidence for a specific mode of action of antidepressants, which, according to the theory of delayed onset of action, is expected to emerge after 2 weeks of therapy. To address the issues of timing on a methodologically sound basis, future trials should adapt a 'longitudinal' rather than 'cross-sectional' design, standardized with respect to a washout period, baseline and first 2 week assessments. With this in mind, special attention should be paid to parameters which potentially enable the identification of placebo responders, true drug responders and patients at risk of non-improvement. Results and methods of the Zurich meta-analyses may serve as a starting point for further steps in this direction.

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