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Almubrad TM, Ogbuehi KC. Clinical investigation of the effect of topical anesthesia on intraocular pressure. Clin Ophthalmol. 2007;1(3):305-9
Almubrad, T. M., & Ogbuehi, K. C. (2007). Clinical investigation of the effect of topical anesthesia on intraocular pressure. Clinical ophthalmology (Auckland, N.Z.), 1(3), 305-9.
Almubrad, Turki M, and Ogbuehi, Kelechi C. "Clinical investigation of the effect of topical anesthesia on intraocular pressure." Clinical ophthalmology (Auckland, N.Z.) vol. 1,3 (2007): 305-9.
Almubrad TM, Ogbuehi KC. Clinical investigation of the effect of topical anesthesia on intraocular pressure. Clin Ophthalmol. 2007 Sep;1(3):305-9. PMID: 19668485; PMCID: PMC2701119.
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Clin Ophthalmol. 2007 Sep;1(3):305-9.

Clinical investigation of the effect of topical anesthesia on intraocular pressure.

Clinical ophthalmology (Auckland, N.Z.)

Turki M Almubrad, Kelechi C Ogbuehi

Affiliations

  1. Department of Optometry and Vision Sciences, College of Applied Medical Sciences, Kingdom of Saudi Arabia.

PMID: 19668485 PMCID: PMC2701119

Abstract

BACKGROUND/AIMS: Contact tonometry is generally considered more accurate than non-contact tonometry in the assessment of intraocular pressure (IOP). This study was designed to investigate the effect of ocular anesthesia, a pre-requisite for contact tonometry, on the IOP in a sample of visually normal subjects.

METHOD: In a random sample of 120 young visually normal subjects (divided equally among three groups), the Topcon CT80 non-contact tonometer was used to measure IOP before, at the second minute and at the fifth minute following instillation of one drop of one of three eyedrops - carboxymethylcellulose sodium 0.5% (control), oxybuprocaine hydrochloride 0.4% and proparacaine hydrochloride 0.5%.

RESULTS: The IOP measured before instilling the ophthalmic drops did not vary significantly among the three groups of subjects (p > 0.05). In the control group, the average IOP of 15.1 +/- 2.6 mmHg did not vary significantly (p > 0.05) 2 minutes and 5 minutes following instillation of one drop of Carboxymethylcellulose sodium. There were statistically significant reductions of IOP 2 minutes (p < 0.01) and 5 minutes (p < 0.001) after the instillation of one drop of oxybuprocaine hydrochloride. One drop of proparacaine hydrochloride caused significant reductions in the average IOP after 2 minutes (p < 0.001) and after 5 minutes (p < 0.001).

CONCLUSIONS: One drop of topical proparacaine or oxybuprocaine may cause a small but a statistically significant reduction in IOP which could lead to lower IOP readings.

Keywords: oxybuprocaine; proparacaine; tonometry; topical anesthesia

References

  1. J Cataract Refract Surg. 2001 Nov;27(11):1787-91 - PubMed
  2. Acta Ophthalmol (Copenh). 1992 Dec;70(6):740-4 - PubMed
  3. Optom Vis Sci. 1999 Mar;76(3):164-9 - PubMed
  4. Cornea. 2003 Aug;22(6):527-32 - PubMed
  5. Ophthalmologica. 1994;208(6):309-13 - PubMed
  6. Ophthalmic Physiol Opt. 1995 Jul;15(4):299-304 - PubMed
  7. Am J Optom Physiol Opt. 1983 Apr;60(4):308-10 - PubMed
  8. Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2912-7 - PubMed
  9. Cornea. 2007 Jan;26(1):55-8 - PubMed
  10. Cornea. 2006 Jan;25(1):51-4 - PubMed
  11. Doc Ophthalmol. 1986 Jan 15;61(3-4):295-301 - PubMed
  12. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3026-31 - PubMed
  13. Am J Ophthalmol. 2007 Jan;143(1):39-47 - PubMed
  14. Arch Ophtalmol Rev Gen Ophtalmol. 1974 Feb;34(2):121-32 - PubMed
  15. Eye (Lond). 2005 Mar;19(3):327-32 - PubMed
  16. Clin Exp Optom. 2006 Sep;89(5):310-4 - PubMed
  17. S Afr Med J. 1987 May 2;71(9):570-1 - PubMed

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