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Fizanne L, Régenet N, Wang J, et al. Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension. Hepatol Int. 2008;2(4):457-64doi: 10.1007/s12072-008-9070-5.
Fizanne, L., Régenet, N., Wang, J., Oberti, F., Moal, F., Roux, J., Gallois, Y., Michalak, S., & Calès, P. (2008). Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension. Hepatology international, 2(4), 457-64. https://doi.org/10.1007/s12072-008-9070-5
Fizanne, Lionel, et al. "Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension." Hepatology international vol. 2,4 (2008): 457-64. doi: https://doi.org/10.1007/s12072-008-9070-5
Fizanne L, Régenet N, Wang J, Oberti F, Moal F, Roux J, Gallois Y, Michalak S, Calès P. Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension. Hepatol Int. 2008 Dec;2(4):457-64. doi: 10.1007/s12072-008-9070-5. Epub 2008 Apr 12. PMID: 19669320; PMCID: PMC2716898.
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Hepatol Int. 2008 Dec;2(4):457-64. doi: 10.1007/s12072-008-9070-5. Epub 2008 Apr 12.

Hemodynamic effects of the early and long-term administration of propranolol in rats with intrahepatic portal hypertension.

Hepatology international

Lionel Fizanne, Nicolas Régenet, Jianhua Wang, Frédéric Oberti, Frédéric Moal, Jerôme Roux, Yves Gallois, Sophie Michalak, Paul Calès

Affiliations

  1. Laboratoire HIFIH, UPRES EA 3859, UFR de Médecine, Université d'Angers, Angers, France.

PMID: 19669320 PMCID: PMC2716898 DOI: 10.1007/s12072-008-9070-5

Abstract

Background and aims The aims of this study were to evaluate a preventive effect on collateral venous circulation of long-term administration of propranolol in intrahepatic portal hypertensive rats. Methods Eighty-six Sprague-Dawley rats were allocated to two models of hepatic fibrosis, bile duct-ligated (BDL) induced and carbon tetrachloride (CCl(4)) induced. Each model was divided into two groups: one receiving placebo and the other propranolol (75 mg kg(-1) d(-1)). Mean arterial pressure (MAP), heart rate (HR), portal pressure (PP), cardiac index (CI), vascular systemic resistance, and splenorenal shunt blood flow (SRS-BF) were measured in anesthetized rats. Results In the BDL model, no significant hemodynamic changes were observed in the propranolol group compared with the placebo group. In CCl(4)-induced rats, HR (390 +/- 50 vs. 329 +/- 51 beats/min, P = .001), CI (44 +/- 11 vs. 34 +/- 10 ml/min, P = .004), PP (15.4 +/- 3.0 vs. 13.4 +/- 1.9 mmHg, P = .045), and SRS-BF (1.4 +/- 1.1 vs. 1.0 +/- 1.0 ml/min, P = .047) were significantly lower in the propranolol group. Conclusions This study showed that propranolol has a significant hemodynamic effect only in the CCl(4) model and suggested a model-dependent effect of propranolol.

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