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Chen YC, Chu CM, Yeh CT, et al. Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study. Hepatol Int. 2007;1(1):267-73doi: 10.1007/s12072-007-5001-0.
Chen, Y. C., Chu, C. M., Yeh, C. T., & Liaw, Y. F. (2007). Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study. Hepatology international, 1(1), 267-73. https://doi.org/10.1007/s12072-007-5001-0
Chen, Yi-Cheng, et al. "Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study." Hepatology international vol. 1,1 (2007): 267-73. doi: https://doi.org/10.1007/s12072-007-5001-0
Chen YC, Chu CM, Yeh CT, Liaw YF. Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study. Hepatol Int. 2007 Mar;1(1):267-73. doi: 10.1007/s12072-007-5001-0. PMID: 19669348; PMCID: PMC2720722.
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Hepatol Int. 2007 Mar;1(1):267-73. doi: 10.1007/s12072-007-5001-0.

Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study.

Hepatology international

Yi-Cheng Chen, Chia-Ming Chu, Chau-Ting Yeh, Yun-Fan Liaw

Affiliations

  1. Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199, Tung Hwa North Road, Taipei, 105, Taiwan, [email protected].

PMID: 19669348 PMCID: PMC2720722 DOI: 10.1007/s12072-007-5001-0

Abstract

PURPOSE: To elucidate the long-term natural course following the onset of cirrhosis in patients with chronic hepatitis B.

METHODS: Ninety-three patients with chronic hepatitis B who had developed cirrhosis during regular follow-up were included in this long-term follow-up study. At the time of cirrhosis detection, 30% of the patients were seropositive for hepatitis B e antigen (HBeAg) and 73% had a HBV-DNA level >10(4) copies/ml. Follow-up studies included liver biochemistry, viral markers, alpha-fetoprotein and ultrasonography every 3-6 months.

RESULTS: During a mean follow-up period of 102 +/- 60 (12-246; median 97) months, 32 patients (34.4%) experienced 55 episodes of hepatitis flare (7.0%/year), 15 (53.6%) of 28 HBeAg-positive patients seroconverted to anti-HBe (6.3%/yr) and 12 (12.9%) lost HBsAg (1.5%/year). Overall disease progression was observed in 25 (26.9%, 3.2%/year) patients: 12 (12.9%, 1.5%/year) hepatic decompensation, 21 (22.6%, 2.7%/year) hepatocellular carcinoma and 11 (11.8%, 1.4%/year) died. Multivariate analysis showed that age at onset of cirrhosis (P = 0.015) and persistent HBeAg seropositivity (P = 0.019) were the independent factors for overall disease progression.

CONCLUSIONS: These results suggest that patients with older age at onset of cirrhosis and persistent HBeAg seropositivity following the onset of cirrhosis were independent factors for the disease progression in the first 10-year after the development of cirrhosis in patients with chronic hepatitis B.

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