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Modolo J, Henry J, Beuter A. Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation. J Biol Phys. 2008;34(3):251-66doi: 10.1007/s10867-008-9095-y.
Modolo, J., Henry, J., & Beuter, A. (2008). Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation. Journal of biological physics, 34(3), 251-66. https://doi.org/10.1007/s10867-008-9095-y
Modolo, J, et al. "Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation." Journal of biological physics vol. 34,3 (2008): 251-66. doi: https://doi.org/10.1007/s10867-008-9095-y
Modolo J, Henry J, Beuter A. Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation. J Biol Phys. 2008 Aug;34(3):251-66. doi: 10.1007/s10867-008-9095-y. Epub 2008 Aug 01. PMID: 19669474; PMCID: PMC2585637.
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J Biol Phys. 2008 Aug;34(3):251-66. doi: 10.1007/s10867-008-9095-y. Epub 2008 Aug 01.

Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation.

Journal of biological physics

J Modolo, J Henry, A Beuter

Affiliations

  1. Laboratoire Intégration du Matériau au Système, CNRS UMR 5218, Université Bordeaux 1, Talence, France. [email protected]

PMID: 19669474 PMCID: PMC2585637 DOI: 10.1007/s10867-008-9095-y

Abstract

The dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation (DBS) were studied using two models, a simple firing-rate model and a population-based model. We extended the simple firing-rate model of the complex formed by the subthalamic nucleus (STN) and the external segment of the Globus Pallidus (GPe) to explore its dynamical regime during DBS. More specifically, the modulation of neuronal activity (i.e., pattern and amplitude) during DBS was studied. A similar approach was used with the population-based model. Simulation results revealed a gradual decrease in bursting activity in STN cells when the DBS frequency increased. In addition, the contribution of the stimulation current type (mono- or biphasic) to the results was also examined. A comparison of the two models indicated that the population-based model was more biologically realistic and more appropriate for exploring DBS mechanisms. Understanding the underlying mechanisms of DBS is a prerequisite for developing new stimulation protocols.

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