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Caro E, Castellano MM, Gutierrez C. GEM, a Novel Factor in the Coordination of Cell Division to Cell Fate Decisions in the Arabidopsis Epidermis. Plant Signal Behav. 2007;2(6):494-5doi: 10.4161/psb.2.6.4579.
Caro, E., Castellano, M. M., & Gutierrez, C. (2007). GEM, a Novel Factor in the Coordination of Cell Division to Cell Fate Decisions in the Arabidopsis Epidermis. Plant signaling & behavior, 2(6), 494-5. https://doi.org/10.4161/psb.2.6.4579
Caro, Elena, et al. "GEM, a Novel Factor in the Coordination of Cell Division to Cell Fate Decisions in the Arabidopsis Epidermis." Plant signaling & behavior vol. 2,6 (2007): 494-5. doi: https://doi.org/10.4161/psb.2.6.4579
Caro E, Castellano MM, Gutierrez C. GEM, a Novel Factor in the Coordination of Cell Division to Cell Fate Decisions in the Arabidopsis Epidermis. Plant Signal Behav. 2007 Nov;2(6):494-5. doi: 10.4161/psb.2.6.4579. PMID: 19704596; PMCID: PMC2634346.
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Plant Signal Behav. 2007 Nov;2(6):494-5. doi: 10.4161/psb.2.6.4579.

GEM, a Novel Factor in the Coordination of Cell Division to Cell Fate Decisions in the Arabidopsis Epidermis.

Plant signaling & behavior

Elena Caro, M Mar Castellano, Crisanto Gutierrez

Affiliations

  1. Centro de Biología Molecular "Severo Ochoa"; Consejo Superior de Investigaciones Científicas; Universidad Autónoma de Madrid; Madrid, Spain.

PMID: 19704596 PMCID: PMC2634346 DOI: 10.4161/psb.2.6.4579

Abstract

Cell division and cell fate decisions are highly regulated processes that need to be coordinated both spatially and temporally for correct plant growth and development. Gaining a deeper molecular and cellular understanding of these links is especially relevant for plant biology since, unlike in animals, formation of new organs is a process that takes place after embryogenesis and continues throughout the entire plant lifespan. The recent identification of a novel factor, GEM, has provided a molecular framework that coordinates cell division to cell fate in the Arabidopsis epidermis. GEM is an inhibitor of cell division through interacting with CDT1, a DNA replication protein. It also inhibits the expression of the homeobox GLABRA2 (GL2) gene that determines the hair/non-hair fate and the pavement/trichome fate in the root and leaf epidermis, respectively. GEM seems to be crucial in controlling the balance of activating/repressing histone modifications at its target promoters.

Keywords: Arabidopsis; CDT1; DNA replication; GEM; GLABRA2; cell cycle; cell division; cell fate; chromatin; gene expression; histone methylation; plant; root hair

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