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Roelfsema F, Biermasz NR, Pereira AM, et al. Therapeutic options in the management of acromegaly: focus on lanreotide Autogel. Biologics. 2008;2(3):463-79doi: 10.2147/btt.s3356.
Roelfsema, F., Biermasz, N. R., Pereira, A. M., & Romijn, J. A. (2008). Therapeutic options in the management of acromegaly: focus on lanreotide Autogel. Biologics : targets & therapy, 2(3), 463-79. https://doi.org/10.2147/btt.s3356
Roelfsema, Ferdinand, et al. "Therapeutic options in the management of acromegaly: focus on lanreotide Autogel." Biologics : targets & therapy vol. 2,3 (2008): 463-79. doi: https://doi.org/10.2147/btt.s3356
Roelfsema F, Biermasz NR, Pereira AM, Romijn JA. Therapeutic options in the management of acromegaly: focus on lanreotide Autogel. Biologics. 2008 Sep;2(3):463-79. doi: 10.2147/btt.s3356. PMID: 19707377; PMCID: PMC2721386.
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Biologics. 2008 Sep;2(3):463-79. doi: 10.2147/btt.s3356.

Therapeutic options in the management of acromegaly: focus on lanreotide Autogel.

Biologics : targets & therapy

Ferdinand Roelfsema, Nienke R Biermasz, Alberto M Pereira, Johannes A Romijn

Affiliations

  1. Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 19707377 PMCID: PMC2721386 DOI: 10.2147/btt.s3356

Abstract

BACKGROUND: In acromegaly, expert surgery is curative in only about 60% of patients. Postoperative radiation therapy is associated with a high incidence of hypopituitarism and its effect on growth hormone (GH) production is slow, so that adjuvant medical treatment becomes of importance in the management of many patients.

OBJECTIVE: To delineate the role of lanreotide in the treatment of acromegaly.

METHODS: Search of Medline, Embase, and Web of Science databases for clinical studies of lanreotide in acromegaly.

RESULTS: Treatment with lanreotide slow release and lanreotide Autogel((R)) normalized GH and insulin-like growth factor-I (IGF-I) concentrations in about 50% of patients. The efficacy of 120 mg lanreotide Autogel((R)) on GH and IGF-I levels was comparable with that of 20 mg octreotide LAR. There were no differences in improvement of cardiac function, decrease in pancreatic beta-cell function, or occurrence of side effects, including cholelithiasis, between octreotide LAR and lanreotide Autogel(R). When postoperative treatment with somatostatin analogs does not result in normalization of serum IGF-I and GH levels after noncurative surgery, pegvisomant alone or in combination with somatostatin analogs can control these levels in a substantial number of patients.

Keywords: acromegaly; growth hormone; lanreotide; pegvisomant; somatostatin analog

References

  1. J Clin Endocrinol Metab. 2000 Nov;85(11):4099-103 - PubMed
  2. J Neurosurg. 1996 Aug;85(2):239-47 - PubMed
  3. Clin Endocrinol (Oxf). 2005 Aug;63(2):176-84 - PubMed
  4. Clin Endocrinol (Oxf). 2008 Mar;68(3):458-65 - PubMed
  5. J Clin Endocrinol Metab. 1999 Oct;84(10):3551-5 - PubMed
  6. J Clin Endocrinol Metab. 1997 Oct;82(10):3187-91 - PubMed
  7. J Clin Endocrinol Metab. 2002 Apr;87(4):1909; author reply 1909 - PubMed
  8. J Clin Endocrinol Metab. 2005 Oct;90(10):5627-31 - PubMed
  9. J Clin Endocrinol Metab. 2007 Dec;92(12):4598-601 - PubMed
  10. J Clin Endocrinol Metab. 1994 Jul;79(1):145-51 - PubMed
  11. J Clin Endocrinol Metab. 2001 Jul;86(7):2929-34 - PubMed
  12. Neuro Endocrinol Lett. 2003 Oct;24(5):334-8 - PubMed
  13. Clin Endocrinol (Oxf). 2006 Feb;64(2):209-14 - PubMed
  14. Endocrinol Metab Clin North Am. 2008 Mar;37(1):101-22, viii - PubMed
  15. IDrugs. 2007 Dec;10(12):885-95 - PubMed
  16. Pituitary. 2007;10(3):237-49 - PubMed
  17. N Engl J Med. 2000 Apr 20;342(16):1171-7 - PubMed
  18. Clin Endocrinol (Oxf). 2004 Aug;61(2):209-15 - PubMed
  19. J Clin Endocrinol Metab. 2005 Mar;90(3):1856-63 - PubMed
  20. J Endocrinol Invest. 1999 Jun;22(6):409-18 - PubMed
  21. Treat Endocrinol. 2005;4(1):43-53 - PubMed
  22. J Neurochem. 2004 Jun;89(5):1057-91 - PubMed
  23. Clin Endocrinol (Oxf). 2003 Jul;59(1):115-28 - PubMed
  24. J Clin Endocrinol Metab. 2005 Aug;90(8):4465-73 - PubMed
  25. Clin Endocrinol (Oxf). 2000 May;52(5):549-55 - PubMed
  26. J Clin Endocrinol Metab. 2005 Jul;90(7):4081-6 - PubMed
  27. Pituitary. 2007;10(1):19-25 - PubMed
  28. Endocrinol Metab Clin North Am. 1992 Sep;21(3):713-35 - PubMed
  29. Clin Endocrinol (Oxf). 1996 Oct;45(4):415-21 - PubMed
  30. Eur J Endocrinol. 2007 Nov;157(5):579-87 - PubMed
  31. Clin Endocrinol (Oxf). 2003 Oct;59(4):492-9 - PubMed
  32. Clin Endocrinol (Oxf). 1999 May;50(5):561-7 - PubMed
  33. Neuroendocrinology. 2006;83(3-4):230-9 - PubMed
  34. Q J Med. 1970 Jan;39(153):1-16 - PubMed
  35. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10258-62 - PubMed
  36. Clin Endocrinol (Oxf). 2008 Aug;69(2):299-305 - PubMed
  37. Eur J Endocrinol. 2005 Aug;153(2):239-48 - PubMed
  38. Eur J Endocrinol. 1994 Jun;130(6):581-6 - PubMed
  39. J Clin Endocrinol Metab. 1989 Dec;69(6):1225-33 - PubMed
  40. BMJ. 1992 May 23;304(6838):1343-6 - PubMed
  41. Biophys J. 2008 Mar 1;94(5):1782-95 - PubMed
  42. J Clin Endocrinol Metab. 2003 Aug;88(8):3567-72 - PubMed
  43. Endocr Rev. 2004 Feb;25(1):102-52 - PubMed
  44. J Clin Endocrinol Metab. 2003 Nov;88(11):5258-65 - PubMed
  45. Eur J Endocrinol. 1999 Sep;141(3):267-71 - PubMed
  46. Clin Endocrinol (Oxf). 2008 Mar;68(3):343-9 - PubMed
  47. J Clin Endocrinol Metab. 2001 Jul;86(7):2935-41 - PubMed
  48. Br J Clin Pharmacol. 1994 Sep;38(3):213-9 - PubMed
  49. J Clin Endocrinol Metab. 2006 Jun;91(6):2112-8 - PubMed
  50. J Clin Endocrinol Metab. 1998 Feb;83(2):374-8 - PubMed
  51. J Clin Invest. 2004 Aug;114(3):349-56 - PubMed
  52. Clin Endocrinol (Oxf). 2005 Jun;62(6):742-7 - PubMed
  53. Eur J Endocrinol. 2004 Apr;150(4):489-95 - PubMed
  54. Clin Endocrinol (Oxf). 1999 Aug;51(2):159-64 - PubMed
  55. Eur J Endocrinol. 1998 Feb;138(2):160-3 - PubMed
  56. N Engl J Med. 2007 Jan 4;356(1):29-38 - PubMed
  57. Eur J Endocrinol. 2007 Jan;156(1):75-82 - PubMed
  58. Eur J Endocrinol. 2004 Apr;150(4):465-71 - PubMed
  59. Lancet. 2001 Nov 24;358(9295):1754-9 - PubMed
  60. J Clin Endocrinol Metab. 1997 Jan;82(1):18-22 - PubMed
  61. J Clin Endocrinol Metab. 2001 Jul;86(7):2976-81 - PubMed
  62. J Clin Endocrinol Metab. 2001 Apr;86(4):1645-52 - PubMed
  63. Metabolism. 2002 Mar;51(3):387-93 - PubMed
  64. J Clin Endocrinol Metab. 2004 Feb;89(2):667-74 - PubMed
  65. J Clin Endocrinol Metab. 2004 Apr;89(4):1613-7 - PubMed
  66. Horm Res. 2007;68 Suppl 5:166-72 - PubMed
  67. J Clin Endocrinol Metab. 2000 May;85(5):2068-71 - PubMed
  68. Pituitary. 2000 May;2(4):269-76 - PubMed
  69. Front Neuroendocrinol. 1999 Jul;20(3):157-98 - PubMed
  70. Acta Med Scand. 1988;223(4):327-35 - PubMed
  71. Clin Endocrinol (Oxf). 2006 Sep;65(3):320-6 - PubMed
  72. Trends Endocrinol Metab. 2000 May-Jun;11(4):132-7 - PubMed
  73. Clin Endocrinol (Oxf). 2005 Nov;63(5):514-9 - PubMed
  74. Am J Cardiol. 1999 May 15;83(10):1506-9, A8 - PubMed
  75. Int J Nanomedicine. 2006;1(4):385-98 - PubMed
  76. Am J Physiol. 1986 Mar;250(3 Pt 1):E269-73 - PubMed
  77. J Clin Endocrinol Metab. 2005 May;90(5):2731-9 - PubMed
  78. J Clin Endocrinol Metab. 2000 Dec;85(12):4596-602 - PubMed
  79. Endocr Rev. 2001 Feb;22(1):53-74 - PubMed
  80. J Clin Endocrinol Metab. 1995 May;80(5):1577-83 - PubMed
  81. J Clin Pharmacol. 2005 Jul;45(7):836-44 - PubMed
  82. Medicine (Baltimore). 1994 Sep;73(5):233-40 - PubMed
  83. J Clin Endocrinol Metab. 2004 Jan;89(1):71-5 - PubMed
  84. Acta Neurochir (Wien). 1999;141(4):399-405 - PubMed
  85. J Clin Endocrinol Metab. 1967 Oct;27(10):1418-30 - PubMed
  86. Pituitary. 2007;10(2):115-9 - PubMed
  87. J Clin Endocrinol Metab. 2003 Jul;88(7):3105-12 - PubMed
  88. J Clin Endocrinol Metab. 1991 May;72(5):1048-53 - PubMed
  89. J Clin Endocrinol Metab. 1997 Oct;82(10):3308-14 - PubMed
  90. Growth Horm IGF Res. 2005 Jun;15(3):200-6 - PubMed
  91. J Clin Endocrinol Metab. 2005 Aug;90(8):4483-8 - PubMed
  92. Eur J Endocrinol. 2005 Jul;153(1):67-71 - PubMed
  93. Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):139-44 - PubMed
  94. Clin Endocrinol (Oxf). 1980 Jan;12(1):53-9 - PubMed
  95. Eur J Endocrinol. 1994 Mar;130(3):229-34 - PubMed
  96. Rev Endocr Metab Disord. 2008 Mar;9(1):41-58 - PubMed
  97. J Clin Endocrinol Metab. 2005 Jun;90(6):3337-41 - PubMed
  98. Eur J Endocrinol. 1994 Jul;131(1):20-6 - PubMed
  99. J Neurosurg. 1998 Sep;89(3):353-8 - PubMed
  100. Clin Endocrinol (Oxf). 2007 Oct;67(4):512-9 - PubMed
  101. Clin Endocrinol (Oxf). 2004 Jun;60(6):734-40 - PubMed
  102. J Neurosurg. 1998 Jun;88(6):1002-8 - PubMed
  103. Eur J Endocrinol. 2000 Nov;143(5):577-84 - PubMed
  104. J Neurosurg. 2005 Apr;102(4):678-91 - PubMed
  105. Clin Endocrinol (Oxf). 2008 Mar;68(3):473-80 - PubMed
  106. J Endocrinol Invest. 2003 Jun;26(6):533-8 - PubMed
  107. Metabolism. 1992 Sep;41(9 Suppl 2):22-33 - PubMed
  108. Eur J Endocrinol. 2008 Mar;158(3):295-303 - PubMed
  109. Eur J Endocrinol. 2004 Apr;150(4):473-80 - PubMed
  110. Psychother Psychosom. 1999;68(3):165-7 - PubMed
  111. Clin Endocrinol (Oxf). 2000 Nov;53(5):577-86 - PubMed
  112. Zentralbl Neurochir. 2005 Aug;66(3):126-32; discussion 132 - PubMed
  113. J Clin Endocrinol Metab. 1999 Feb;84(2):527-32 - PubMed
  114. Pituitary. 2000 Oct;3(2):61-5 - PubMed
  115. J Clin Endocrinol Metab. 1988 Nov;67(5):1040-8 - PubMed
  116. Pituitary. 2007;10(2):121-8 - PubMed
  117. J Endocrinol Invest. 1993 Sep;16(8):565-72 - PubMed
  118. Eur J Endocrinol. 1998 Feb;138(2):164-9 - PubMed
  119. Science. 1973 Jan 5;179(4068):77-9 - PubMed
  120. J Clin Endocrinol Metab. 2005 Jul;90(7):4405-10 - PubMed
  121. Horm Metab Res. 2000 Jun;32(6):224-9 - PubMed
  122. J Clin Endocrinol Metab. 1993 Mar;76(3):721-7 - PubMed
  123. Endocr Rev. 2003 Feb;24(1):28-47 - PubMed
  124. J Clin Endocrinol Metab. 2002 Sep;87(9):4054-8 - PubMed
  125. Eur J Clin Invest. 1997 Apr;27(4):277-84 - PubMed
  126. Clin Endocrinol (Oxf). 1980 Jan;12(1):71-9 - PubMed
  127. Q J Med. 1993 May;86(5):293-9 - PubMed
  128. Eur J Endocrinol. 2001 Aug;145(2):137-45 - PubMed
  129. Clin Endocrinol (Oxf). 2005 Mar;62(3):282-8 - PubMed
  130. Ulster Med J. 1990 Apr;59(1):55-62 - PubMed
  131. J Endocrinol Invest. 1999 Jan;22(1):40-7 - PubMed
  132. J Pharm Pharmacol. 2004 Apr;56(4):471-6 - PubMed
  133. J Clin Endocrinol Metab. 1998 Oct;83(10):3419-26 - PubMed
  134. J Clin Endocrinol Metab. 2003 Jul;88(7):3090-8 - PubMed
  135. N Engl J Med. 1996 Jan 25;334(4):246-54 - PubMed
  136. Eur J Endocrinol. 2006 Dec;155(6):831-7 - PubMed
  137. J Clin Endocrinol Metab. 1994 Dec;79(6):1706-15 - PubMed
  138. Clin Endocrinol (Oxf). 1999 Sep;51(3):275-80 - PubMed
  139. Clin Endocrinol (Oxf). 2008 Jun;68(6):970-5 - PubMed
  140. Eur J Endocrinol. 2007 Apr;156 Suppl 1:S29-S35 - PubMed
  141. Endocr Rev. 2003 Jun;24(3):272-7 - PubMed
  142. Eur J Endocrinol. 2008 Mar;158(3):305-10 - PubMed
  143. J Clin Endocrinol Metab. 2004 Jun;89(6):2789-96 - PubMed
  144. J Clin Endocrinol Metab. 2007 May;92(5):1743-7 - PubMed
  145. Pituitary. 2000 Dec;3(4):231-8 - PubMed
  146. Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E25-30 - PubMed
  147. Eur J Endocrinol. 2005 Aug;153(2):231-8 - PubMed
  148. Clin Endocrinol (Oxf). 2003 Apr;58(4):471-81 - PubMed
  149. Eur J Endocrinol. 2001 Dec;145(6):717-26 - PubMed
  150. J Clin Endocrinol Metab. 2002 Jan;87(1):99-104 - PubMed
  151. J Clin Endocrinol Metab. 1996 Jun;81(6):2356-62 - PubMed
  152. Clin Endocrinol (Oxf). 2000 Sep;53(3):321-7 - PubMed
  153. Clin Endocrinol (Oxf). 2005 Feb;62(2):210-6 - PubMed
  154. Clin Endocrinol (Oxf). 2001 Aug;55(2):183-9 - PubMed
  155. Clin Endocrinol (Oxf). 2003 Jan;58(1):86-91 - PubMed
  156. Pituitary. 2001 Sep;4(4):223-30 - PubMed
  157. J Clin Endocrinol Metab. 2006 Jan;91(1):85-92 - PubMed
  158. Neurosurgery. 2001 Jun;48(6):1239-43; discussion 1244-5 - PubMed
  159. Eur J Clin Invest. 1992 Dec;22(12):793-9 - PubMed
  160. Eur J Endocrinol. 2008 Jan;158(1):19-25 - PubMed
  161. Clin Endocrinol (Oxf). 1994 Jul;41(1):75-83 - PubMed
  162. Eur J Endocrinol. 2005 Mar;152(3):379-87 - PubMed
  163. Clin Endocrinol (Oxf). 2008 Jan;68(1):136-42 - PubMed
  164. Pituitary. 2004;7(4):257-64 - PubMed
  165. Eur J Endocrinol. 2007 Nov;157(5):571-7 - PubMed
  166. Eur J Endocrinol. 2007 Apr;156 Suppl 1:S23-S28 - PubMed
  167. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7088-92 - PubMed
  168. Clin Endocrinol (Oxf). 2003 Feb;58(2):128-31 - PubMed
  169. Lancet. 2005 May 7-13;365(9471):1644-6 - PubMed
  170. J Clin Endocrinol Metab. 1998 Aug;83(8):2730-4 - PubMed
  171. Metabolism. 1996 Aug;45(8 Suppl 1):72-4 - PubMed
  172. Eur J Endocrinol. 2004 Sep;151(3):317-24 - PubMed
  173. Eur J Endocrinol. 2006 Jul;155(1):73-8 - PubMed
  174. Growth Horm IGF Res. 2003 Aug;13 Suppl A:S144-51 - PubMed
  175. J Clin Endocrinol Metab. 2000 Oct;85(10):3779-85 - PubMed
  176. J Clin Endocrinol Metab. 2004 Nov;89(11):5369-76 - PubMed
  177. Clin Endocrinol (Oxf). 2004 Nov;61(5):531-43 - PubMed
  178. Eur J Endocrinol. 2004 Dec;151(6):643-55 - PubMed
  179. Endocrinology. 1992 Apr;130(4):1816-21 - PubMed
  180. Clin Endocrinol (Oxf). 2002 Jan;56(1):65-71 - PubMed
  181. N Engl J Med. 2006 Dec 14;355(24):2558-73 - PubMed
  182. J Clin Endocrinol Metab. 2000 Feb;85(2):526-9 - PubMed
  183. Lancet. 1964 Oct 10;2(7363):769-71 - PubMed
  184. N Engl J Med. 1983 Dec 15;309(24):1495-501 - PubMed
  185. Eur J Endocrinol. 2004 Oct;151(4):439-46 - PubMed
  186. J Clin Endocrinol Metab. 2008 Jan;93(1):61-7 - PubMed
  187. J Clin Endocrinol Metab. 2001 Sep;86(9):4072-7 - PubMed
  188. J Clin Endocrinol Metab. 1995 Sep;80(9):2768-75 - PubMed
  189. Eur J Endocrinol. 2006 Feb;154(2):267-74 - PubMed

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