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Fang RC, Galiano RD. A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics. 2008;2(1):1-12doi: 10.2147/btt.s1338.
Fang, R. C., & Galiano, R. D. (2008). A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics : targets & therapy, 2(1), 1-12. https://doi.org/10.2147/btt.s1338
Fang, Robert C, and Galiano, Robert D. "A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers." Biologics : targets & therapy vol. 2,1 (2008): 1-12. doi: https://doi.org/10.2147/btt.s1338
Fang RC, Galiano RD. A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics. 2008 Mar;2(1):1-12. doi: 10.2147/btt.s1338. PMID: 19707423; PMCID: PMC2727777.
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Biologics. 2008 Mar;2(1):1-12. doi: 10.2147/btt.s1338.

A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers.

Biologics : targets & therapy

Robert C Fang, Robert D Galiano

Affiliations

  1. Division of Plastic and Reconstructive Surgery and Wound Healing Research Laboratory, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

PMID: 19707423 PMCID: PMC2727777 DOI: 10.2147/btt.s1338

Abstract

Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society. While the management of chronic diabetic foot ulcers has improved in recent years, it remains a frustrating problem for a variety of clinicians. This review examines the scientific underpinnings supporting the use of becaplermin (Regranex((R)); Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds. An emphasis is placed upon proper medical and surgical care of diabetic foot wounds, as multiple studies have demonstrated that the success of this growth factor in accelerating healing is ultimately dependent on proper ulcer care. A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.

Keywords: becaplermin; diabetes; foot ulcer; growth factor

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