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Hardin DS. Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin). Biologics. 2008;2(4):655-61doi: 10.2147/btt.s2252.
Hardin, D. S. (2008). Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin). Biologics : targets & therapy, 2(4), 655-61. https://doi.org/10.2147/btt.s2252
Hardin, Dana S. "Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin)." Biologics : targets & therapy vol. 2,4 (2008): 655-61. doi: https://doi.org/10.2147/btt.s2252
Hardin DS. Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin). Biologics. 2008 Dec;2(4):655-61. doi: 10.2147/btt.s2252. PMID: 19707446; PMCID: PMC2727887.
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Biologics. 2008 Dec;2(4):655-61. doi: 10.2147/btt.s2252.

Treatment of short stature and growth hormone deficiency in children with somatotropin (rDNA origin).

Biologics : targets & therapy

Dana S Hardin

Affiliations

  1. Ohio State University and Columbus Children's Hospital, Columbus, Ohio, USA.

PMID: 19707446 PMCID: PMC2727887 DOI: 10.2147/btt.s2252

Abstract

Somatotropin (growth hormone, GH) of recombinant DNA origin has provided a readily available and safe drug that has greatly improved management of children and adolescents with GH deficiency (GHD) and other disorders of growth. In the US and Europe, regulatory agencies have given approval for the use of GH in children and adults who meet specific criteria. However, clinical and ethical controversies remain regarding the diagnosis of GHD, dosing of GH, duration of therapy and expected outcomes. Areas which also require consensus include management of pubertal patients, transitioning pediatric patients to adulthood, management of children with idiopathic short stature and the role of recombinant IGF-1 in treatment. Additionally, studies have demonstrated anabolic benefits of GH in children who have inflammatory-based underlying disease and efficacy of GH in overcoming growth delays in people treated chronically with corticosteroids. These areas are open for possible new uses of this drug. This review summarizes current indications for GH use in children and discusses areas of clinical debate and potential anabolic uses in chronic illness.

Keywords: children; growth hormone deficiency; short stature; somatotropin

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