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Bernheimer AW, Cantoni GL. THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN. J Exp Med. 1945;81(3):295-306doi: 10.1084/jem.81.3.295.
Bernheimer, A. W., & Cantoni, G. L. (1945). THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN. The Journal of experimental medicine, 81(3), 295-306. https://doi.org/10.1084/jem.81.3.295
Bernheimer, A W, and Cantoni, G L. "THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN." The Journal of experimental medicine vol. 81,3 (1945): 295-306. doi: https://doi.org/10.1084/jem.81.3.295
Bernheimer AW, Cantoni GL. THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN. J Exp Med. 1945 Mar 01;81(3):295-306. doi: 10.1084/jem.81.3.295. PMID: 19871458; PMCID: PMC2135492.
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J Exp Med. 1945 Mar 01;81(3):295-306. doi: 10.1084/jem.81.3.295.

THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN.

The Journal of experimental medicine

A W Bernheimer, G L Cantoni

Affiliations

  1. Departments of Bacteriology and Pharmacology, New York University College of Medicine, New York.

PMID: 19871458 PMCID: PMC2135492 DOI: 10.1084/jem.81.3.295

Abstract

1. A study has been made of the effect on the isolated frog's heart of a preparation derived from the supernatant fluid of cultures of hemolytic streptococcus. 2. The streptococcal preparation was found to induce systolic contracture, the contracture usually developing only after the second of two administrations of the preparation. It was found that a single application of the streptococcal preparation sensitized the heart to a second application. 3. The properties of the cardiotoxic factor so far as they have been studied were found to be identical with those of the oxygen-labile hemolysin of streptococci. The capacity of normal and of immune sera to neutralize the cardiotoxic action paralleled the antihemolytic potency of the sera.

References

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