J Gen Physiol. 1924 Jan 20;6(3):245-57. doi: 10.1085/jgp.6.3.245.
The Journal of general physiology
S Brody
PMID: 19872066 PMCID: PMC2140631 DOI: 10.1085/jgp.6.3.245
The course of decline of vitality with age due to the process of senescence, when not complicated by the process of growth, follows a simple exponential law; that is the degree of vitality or of senescence (defining vitality as the reciprocal of senescence) at any moment is, regardless of age, a constant percentage of the degree of vitality or senescence of the preceding moment. This exponential law is the same as the law of monomolecular change in chemistry. During the actively growing period of life the index of vitality rises, due to the process of growth and the course of vitality in the case when the growing period is included in the vitality curve, follows a rising and falling course. This rising and falling course may often be represented by an equation containing two exponential terms which is practically the equation used to represent the course of accumulation and disappearance of a substance as the result of two simultaneous consecutive monomolecular chemical reactions.
