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J Gen Physiol. 1926 Mar 20;9(4):433-43. doi: 10.1085/jgp.9.4.433.

SPEED OF TOXIC ACTION OF ARSENIC IN THE SILKWORM.

The Journal of general physiology

F L Campbell

Affiliations

  1. Entomological Laboratory of the Bussey Institution, Harvard University, Boston.

PMID: 19872265 PMCID: PMC2140834 DOI: 10.1085/jgp.9.4.433

Abstract

A micro burette, micro pipette, and methods for their use in quantitative toxicological investigations on mandibulate insects are described. It is suggested that the form of curves relating speed of toxic action to dosage may be explained by postulating suitable changes in rate of distribution, excretion, and cell penetration of poison as dosage varies. The speed of toxic action of pentavalent arsenic in the silkworm is proportional to an integral power of the dosage at lower concentrations, and to a fractional power of the dosage at higher concentrations.

References

  1. Biochem J. 1925;19(2):270-7 - PubMed

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