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Main RK, Schmidt CL. THE COMBINATION OF DIVALENT MANGANESE WITH CERTAIN PROTEINS, AMINO ACIDS, AND RELATED COMPOUNDS. J Gen Physiol. 1935;19(1):127-47doi: 10.1085/jgp.19.1.127.
Main, R. K., & Schmidt, C. L. (1935). THE COMBINATION OF DIVALENT MANGANESE WITH CERTAIN PROTEINS, AMINO ACIDS, AND RELATED COMPOUNDS. The Journal of general physiology, 19(1), 127-47. https://doi.org/10.1085/jgp.19.1.127
Main, R K, and Schmidt, C L. "THE COMBINATION OF DIVALENT MANGANESE WITH CERTAIN PROTEINS, AMINO ACIDS, AND RELATED COMPOUNDS." The Journal of general physiology vol. 19,1 (1935): 127-47. doi: https://doi.org/10.1085/jgp.19.1.127
Main RK, Schmidt CL. THE COMBINATION OF DIVALENT MANGANESE WITH CERTAIN PROTEINS, AMINO ACIDS, AND RELATED COMPOUNDS. J Gen Physiol. 1935 Sep 20;19(1):127-47. doi: 10.1085/jgp.19.1.127. PMID: 19872906; PMCID: PMC2141415.
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J Gen Physiol. 1935 Sep 20;19(1):127-47. doi: 10.1085/jgp.19.1.127.

THE COMBINATION OF DIVALENT MANGANESE WITH CERTAIN PROTEINS, AMINO ACIDS, AND RELATED COMPOUNDS.

The Journal of general physiology

R K Main, C L Schmidt

Affiliations

  1. Division of Biochemistry, University of California Medical School, Berkeley.

PMID: 19872906 PMCID: PMC2141415 DOI: 10.1085/jgp.19.1.127

Abstract

1. A study of the mode of combination which takes place between certain amino acids, proteins, various carboxylic acids, and certain sulfonic acids and manganous ions to form complexes is reported. 2. Three criteria for complex formation were used: (a) the equilibrium between the substance under test and manganous ions dissolved in aqueous buffered solution and isonitrosoacetophenone dissolved in chloroform; (b) the electrophoretic migration of manganese in the presence of the test substance with varying pH; and (c) anomalous titration. 3. The following classes of substances were found to possess the necessary groupings to form manganese complexes: hydroxy-monocarboxylic acids (lactic, gluconic), dicarboxylic acids (oxalic, malonic), hydroxy-, di- and tricarboxylic acids (citric, tartaric), dicarboxylic amino acids (aspartic, glutamic), certain inorganic acids (phosphoric, sulfuric), certain phosphoric acid-containing compounds (nucleic, glycerophosphoric), certain aromatic enol sulfonic acids (phenolsulfonic, catecholsulfonic), and certain proteins (casein, edestin, gelatin). 4. A correlation between the amount of manganese bound by the several proteins and the free carboxyl and phosphoric acid groups has been made. 5. An explanation based on the residual charge of certain atoms is advanced for the manner in which divalent manganese may be united by the compounds studied.

References

  1. Plant Physiol. 1932 Oct;7(4):697-703 - PubMed
  2. Biochem J. 1930;24(5):1572-90 - PubMed
  3. Science. 1932 Sep 30;76(1970):281-5 - PubMed

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