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Guttman R. ACTION OF POTASSIUM AND NARCOTICS ON RECTIFICATION IN NERVE AND MUSCLE. J Gen Physiol. 1944;28(1):43-51doi: 10.1085/jgp.28.1.43.
Guttman, R. (1944). ACTION OF POTASSIUM AND NARCOTICS ON RECTIFICATION IN NERVE AND MUSCLE. The Journal of general physiology, 28(1), 43-51. https://doi.org/10.1085/jgp.28.1.43
Guttman, R. "ACTION OF POTASSIUM AND NARCOTICS ON RECTIFICATION IN NERVE AND MUSCLE." The Journal of general physiology vol. 28,1 (1944): 43-51. doi: https://doi.org/10.1085/jgp.28.1.43
Guttman R. ACTION OF POTASSIUM AND NARCOTICS ON RECTIFICATION IN NERVE AND MUSCLE. J Gen Physiol. 1944 Sep 20;28(1):43-51. doi: 10.1085/jgp.28.1.43. PMID: 19873404; PMCID: PMC2142595.
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J Gen Physiol. 1944 Sep 20;28(1):43-51. doi: 10.1085/jgp.28.1.43.

ACTION OF POTASSIUM AND NARCOTICS ON RECTIFICATION IN NERVE AND MUSCLE.

The Journal of general physiology

R Guttman

Affiliations

  1. Departments of Hygiene and Chemistry, Brooklyn College, New York, and the Marine Biological Laboratory, Woods Hole, Massachusetts.

PMID: 19873404 PMCID: PMC2142595 DOI: 10.1085/jgp.28.1.43

Abstract

Electrical rectification was demonstrated in whole sartorius muscle and sciatic nerve of Rana pipiens and also in the single giant nerve fiber of the northern squid, Ommastrephes illecibrossus. It is probably a property of the plasma membrane. Rectification decreases reversibly under the influence of increased concentrations of the potassium ion and with chloroform, veratrine sulfate and isoamyl carbamate. No effect was found with lack of calcium, excess calcium, or barium chloride. Decrease in rectification is invariably accompanied by simultaneous decrease in resting potential. A proposed explanation of the mechanism of rectification is discussed. Rectification in a living membrane, viz. a change in resistance with change in direction of current flow, may possibly be explained in terms of a change in the concentration of potassium ions in the membrane.

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