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Nakao M, Sato M, Nomura K, et al. Benzodiazepine prescription and length of hospital stay at a Japanese university hospital. Biopsychosoc Med. 2009;3:10doi: 10.1186/1751-0759-3-10.
Nakao, M., Sato, M., Nomura, K., & Yano, E. (2009). Benzodiazepine prescription and length of hospital stay at a Japanese university hospital. BioPsychoSocial medicine, 310. https://doi.org/10.1186/1751-0759-3-10
Nakao, Mutsuhiro, et al. "Benzodiazepine prescription and length of hospital stay at a Japanese university hospital." BioPsychoSocial medicine vol. 3 (2009): 10. doi: https://doi.org/10.1186/1751-0759-3-10
Nakao M, Sato M, Nomura K, Yano E. Benzodiazepine prescription and length of hospital stay at a Japanese university hospital. Biopsychosoc Med. 2009 Oct 09;3:10. doi: 10.1186/1751-0759-3-10. PMID: 19818119; PMCID: PMC2765986.
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Biopsychosoc Med. 2009 Oct 09;3:10. doi: 10.1186/1751-0759-3-10.

Benzodiazepine prescription and length of hospital stay at a Japanese university hospital.

BioPsychoSocial medicine

Mutsuhiro Nakao, Mikiya Sato, Kyoko Nomura, Eiji Yano

Affiliations

  1. Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan. [email protected]

PMID: 19818119 PMCID: PMC2765986 DOI: 10.1186/1751-0759-3-10

Abstract

BACKGROUND: The relationship between bed days and benzodiazepine prescription (BDZ) in Western countries is inconclusive, and no hospital-based report has documented this phenomenon in Japan. This study was done to assess the association between bed days and BDZ in a Japanese hospital.

METHODS: 21,489 adult patients (55.1% men, mean age 59.9 years old) hospitalized between April, 2005 and December, 2006 were enrolled in the study. Patient age, sex, ICD-10 diagnosis, prescription profile, and days of hospital stay were assessed in 13 non-psychiatric departments using a computer ordering system. Patients prescribed a benzodiazepine during hospitalization were defined as positive.

RESULTS: Of the total sample, 19.9% were allocated to the benzodiazepine (+) group. Female sex and older age were significant factors associated with benzodiazepine prescription. The median number of bed days was 13, and the likelihood of BDZ significantly increased with the number of bed days, even after controlling for the effects of age, gender, and ICD-10 diagnosis. For example, when the analysis was limited to patients with 50 bed days or longer, the percentage of BDZ (32.7%) was equivalent to that of a report from France.

CONCLUSION: Irrespective of department or disease, patients prescribed benzodiazepine during their hospital stay tended to have a higher number of bed days in the hospital. The difference in the prevalence of BDZ between this study and previous Western studies might be attributed to the relatively short length of hospital stay in this study. Because BDZs are often reported to be prescribed to hospitalized patients without appropriate documentation for the indications for use, it is important to monitor the rational for prescriptions of benzodiazepine carefully, for both clinical and economical reasons.

References

  1. J Clin Epidemiol. 2003 Oct;56(10):1021-6 - PubMed
  2. Int J Clin Pharmacol Ther. 2007 Jan;45(1):30-5 - PubMed
  3. Int J Clin Pharmacol Ther. 2005 Aug;43(8):411-2 - PubMed
  4. Psychiatr Serv. 2000 Oct;51(10):1278-81 - PubMed
  5. Pharmacoepidemiol Drug Saf. 2001 Oct-Nov;10(6):531-5 - PubMed
  6. Int J Clin Pharmacol Ther. 2005 Jul;43(7):339-49 - PubMed
  7. Intern Med. 2006;45(22):1279-83 - PubMed
  8. CMAJ. 1990 Mar 15;142(6):585-9 - PubMed
  9. BMJ. 2001 Mar 24;322(7288):704-8 - PubMed
  10. J Clin Psychiatry. 2004;65 Suppl 5:7-12 - PubMed
  11. Psychiatry Clin Neurosci. 2006 Oct;60(5):605-10 - PubMed
  12. J Gen Intern Med. 2007 Jul;22(7):1024-9 - PubMed
  13. J Clin Psychopharmacol. 2002 Jun;22(3):285-93 - PubMed
  14. Eur J Clin Pharmacol. 2005 Jun;61(4):291-5 - PubMed
  15. Best Pract Res Clin Anaesthesiol. 2003 Jun;17(2):219-33 - PubMed
  16. Intern Med. 2007;46(6):255-6 - PubMed
  17. J Pak Med Assoc. 2005 Jun;55(6):259-63 - PubMed
  18. J Affect Disord. 2006 Jan;90(1):29-35 - PubMed
  19. Med J Aust. 1996 Sep 16;165(6):305-8 - PubMed
  20. JAMA. 1997 Jan 22-29;277(4):301-6 - PubMed
  21. J Am Geriatr Soc. 1996 Nov;44(11):1371-4 - PubMed
  22. Am J Psychiatry. 1997 Dec;154(12):1766-8 - PubMed
  23. Drugs Aging. 1998 Jan;12(1):43-53 - PubMed
  24. J Ment Health Adm. 1997 Winter;24(1):90-7 - PubMed
  25. Tohoku J Exp Med. 2007 Jul;212(3):239-46 - PubMed
  26. Am J Med Qual. 1994 Fall;9(3):138-41 - PubMed
  27. Drug Saf. 1991 Jul-Aug;6(4):247-65 - PubMed
  28. BMJ. 1992 Apr 4;304(6831):881 - PubMed
  29. Arch Intern Med. 2004 Jul 26;164(14):1567-72 - PubMed

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