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Brito GN. Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective. Diabetol Metab Syndr. 2009;1(1):7doi: 10.1186/1758-5996-1-7.
Brito, G. N. (2009). Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective. Diabetology & metabolic syndrome, 1(1), 7. https://doi.org/10.1186/1758-5996-1-7
Brito, Gilberto No. "Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective." Diabetology & metabolic syndrome vol. 1,1 (2009): 7. doi: https://doi.org/10.1186/1758-5996-1-7
Brito GN. Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective. Diabetol Metab Syndr. 2009 Sep 18;1(1):7. doi: 10.1186/1758-5996-1-7. PMID: 19825199; PMCID: PMC2761299.
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Diabetol Metab Syndr. 2009 Sep 18;1(1):7. doi: 10.1186/1758-5996-1-7.

Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective.

Diabetology & metabolic syndrome

Gilberto No Brito

Affiliations

  1. Setor de Neurociências, Departamento de Pediatria, Instituto Fernandes Figueira, FIOCRUZ, Rio de Janeiro, RJ, Brasil. [email protected].

PMID: 19825199 PMCID: PMC2761299 DOI: 10.1186/1758-5996-1-7

Abstract

The association of type II diabetes mellitus (DM2) with Alzheimer's disease (AD) has received considerable attention in recent years. In the present paper, a hypothesis for this association from an evolutionary perspective, with emphasis on the close interplay between exercise and cognitive function, will be advanced in order to provide a biological rationale for the notion that the fundamental metabolic features of DM2 act in the brain over a protracted time span to induce the neuropathological characteristics of Alzheimer's disease thereby producing cognitive impairment. It is hoped that this hypothesis puts the association of DM2 and AD on firm conceptual grounds from a biological perspective and offers directions for further research.

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