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Salomone S, Caraci F, Capasso A. Migraine: an overview. Open Neurol J. 2009;3:64-71doi: 10.2174/1874205X00903010064.
Salomone, S., Caraci, F., & Capasso, A. (2009). Migraine: an overview. The open neurology journal, 364-71. https://doi.org/10.2174/1874205X00903010064
Salomone, Salvatore, et al. "Migraine: an overview." The open neurology journal vol. 3 (2009): 64-71. doi: https://doi.org/10.2174/1874205X00903010064
Salomone S, Caraci F, Capasso A. Migraine: an overview. Open Neurol J. 2009 Oct 01;3:64-71. doi: 10.2174/1874205X00903010064. PMID: 19888434; PMCID: PMC2771268.
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Open Neurol J. 2009 Oct 01;3:64-71. doi: 10.2174/1874205X00903010064.

Migraine: an overview.

The open neurology journal

Salvatore Salomone, Filippo Caraci, Anna Capasso

Affiliations

  1. Department of Pharmacology University of Catania.

PMID: 19888434 PMCID: PMC2771268 DOI: 10.2174/1874205X00903010064

Abstract

The pathophysiology of migraine is not completely understood and continues to be investigated. The complexity of interactions taking place in the sensory neuronal network with the mediation of all different neurotransmitters involved gives the measure of the extreme difficulty connected with the knowledge of migraine pathogenesis and in particular of its cardinal sign. Neuronal components are relevant in migraine pathophysiology: there could be a generalized interictal abnormal excitability of the cerebral cortex in migraine, possibly favoring the occurrence of spreading depression with consequent activation of the trigeminal system. Many theories have been formulated in these last sixty years about the pathogenesis of migraine and other forms of primary headache, but the problem is still far to be fully clarified. The present review is focused on the description of different theories on the migraine pathogenesis. This review is dedicated to the memory of Prof. Alfredo Bianchi.

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