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Munos B. Lessons from 60 years of pharmaceutical innovation. Nat Rev Drug Discov. 2009;8(12):959-68doi: 10.1038/nrd2961.
Munos, B. (2009). Lessons from 60 years of pharmaceutical innovation. Nature reviews. Drug discovery, 8(12), 959-68. https://doi.org/10.1038/nrd2961
Munos, Bernard. "Lessons from 60 years of pharmaceutical innovation." Nature reviews. Drug discovery vol. 8,12 (2009): 959-68. doi: https://doi.org/10.1038/nrd2961
Munos B. Lessons from 60 years of pharmaceutical innovation. Nat Rev Drug Discov. 2009 Dec;8(12):959-68. doi: 10.1038/nrd2961. PMID: 19949401.
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Nat Rev Drug Discov. 2009 Dec;8(12):959-68. doi: 10.1038/nrd2961.

Lessons from 60 years of pharmaceutical innovation.

Nature reviews. Drug discovery

Bernard Munos

Affiliations

  1. Lilly Corporate Center, Indianapolis, Indiana 46285, USA. [email protected]

PMID: 19949401 DOI: 10.1038/nrd2961

Abstract

Despite unprecedented investment in pharmaceutical research and development (R&D), the number of new drugs approved by the US Food and Drug Administration (FDA) remains low. To help understand this conundrum, this article investigates the record of pharmaceutical innovation by analysing data on the companies that introduced the approximately 1,200 new drugs that have been approved by the FDA since 1950. This analysis shows that the new-drug output from pharmaceutical companies in this period has essentially been constant, and remains so despite the attempts to increase it. This suggests that, contrary to common perception, the new-drug output is not depressed, but may simply reflect the limitations of the current R&D model. The implications of these findings and options to achieve sustainability for the pharmaceutical industry are discussed.

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