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Di Biagio A, Rosso R, Monteforte P, et al. Whole body bone scintigraphy in tenofovir-related osteomalacia: a case report. J Med Case Rep. 2009;3:8136doi: 10.4076/1752-1947-3-8136.
Di Biagio, A., Rosso, R., Monteforte, P., Russo, R., Rovetta, G., & Viscoli, C. (2009). Whole body bone scintigraphy in tenofovir-related osteomalacia: a case report. Journal of medical case reports, 38136. https://doi.org/10.4076/1752-1947-3-8136
Di Biagio, Antonio, et al. "Whole body bone scintigraphy in tenofovir-related osteomalacia: a case report." Journal of medical case reports vol. 3 (2009): 8136. doi: https://doi.org/10.4076/1752-1947-3-8136
Di Biagio A, Rosso R, Monteforte P, Russo R, Rovetta G, Viscoli C. Whole body bone scintigraphy in tenofovir-related osteomalacia: a case report. J Med Case Rep. 2009 Jul 22;3:8136. doi: 10.4076/1752-1947-3-8136. PMID: 19830218; PMCID: PMC2737799.
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J Med Case Rep. 2009 Jul 22;3:8136. doi: 10.4076/1752-1947-3-8136.

Whole body bone scintigraphy in tenofovir-related osteomalacia: a case report.

Journal of medical case reports

Antonio Di Biagio, Raffaella Rosso, Patrizia Monteforte, Rodolfo Russo, Guido Rovetta, Claudio Viscoli

PMID: 19830218 PMCID: PMC2737799 DOI: 10.4076/1752-1947-3-8136

Abstract

INTRODUCTION: Tenofovir disoproxil fumarate (Viread((R))) is the only nucleotide reverse transcriptase inhibitor currently approved for the treatment of HIV. It is frequently prescribed not only for its efficacy but also for its decreased side effect profile compared with other nucleotide analogs. In addition, it is now increasingly recognized as a cause of acquired Fanconi's syndrome in individuals with HIV.

CASE PRESENTATION: We describe a 48-year-old woman infected with HIV, with chronic renal insufficiency, who developed Fanconi's syndrome after inclusion of tenofovir disoproxil fumarate in her antiretroviral therapy. A whole body bone scintigraphy was performed, revealing an abnormal distribution of radiotracer uptake, with characteristic changes compatible with osteomalacia. All symptoms disappeared after tenofovir discontinuation and mineral supplementation. No other explanation for the sudden and complete resolution of the bone disease was found.

CONCLUSION: The case highlights the role of whole body bone scintigraphy in the diagnosis of tenofovir-related osteomalacia.

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