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Cases J. 2009 Sep 16;2:6792. doi: 10.4076/1757-1626-2-6792.

Nodular glomerulosclerosis in patients' without history of diabetes mellitus: a case report.

Cases journal

Imed Helal, Rym Goucha, Cyrine Karoui, Ezzedine Abderrahim, Fethi Ben Hamida, Fethi Elyounsi, Hedi Ben Maiz, Taieb Ben Abdallah, Adel Kheder

Affiliations

  1. Department of Internal Medicine A and Laboratory of Kidney Pathology 02, Charles Nicolle Hospital Boulevard 9 Avril. 1006 Tunis Tunisia. [email protected]

PMID: 19918545 PMCID: PMC2769315 DOI: 10.4076/1757-1626-2-6792

Abstract

INTRODUCTION: Diabetic nephropathy can occur during the course of both type1 and type 2 diabetes mellitus. The characteristic lesions are diffuse or nodular (Kimmelsteil-Wilson) diabetic glomerulosclerosis. The reported cases represent unusual presentations of diabetes mellitus.

CASE PRESENTATION: We report the case of a 49-year-old man without prior history of diabetes mellitus who presented with rapidly progressive renal failure and whose renal biopsy revealed nodular (Kimmelsteil-Wilson) glomerulosclerosis lesions characteristic of diabetes.

CONCLUSION: Renal manifestations of diabetes mellitus may antedate other more common presenting symptoms of this disease and we critically review the literature on this subject.

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