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Fazal N. Expression or possession of catalase gene does not alter the capacity of M. smegmatis to survive within human macrophages. Biochem Mol Biol Int. 1997;42(4):843-51doi: 10.1080/15216549700203281.
Fazal, N. (1997). Expression or possession of catalase gene does not alter the capacity of M. smegmatis to survive within human macrophages. Biochemistry and molecular biology international, 42(4), 843-51. https://doi.org/10.1080/15216549700203281
Fazal, N. "Expression or possession of catalase gene does not alter the capacity of M. smegmatis to survive within human macrophages." Biochemistry and molecular biology international vol. 42,4 (1997): 843-51. doi: https://doi.org/10.1080/15216549700203281
Fazal N. Expression or possession of catalase gene does not alter the capacity of M. smegmatis to survive within human macrophages. Biochem Mol Biol Int. 1997 Jul;42(4):843-51. doi: 10.1080/15216549700203281. PMID: 19856302.
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Biochem Mol Biol Int. 1997 Jul;42(4):843-51. doi: 10.1080/15216549700203281.

Expression or possession of catalase gene does not alter the capacity of M. smegmatis to survive within human macrophages.

Biochemistry and molecular biology international

N Fazal

Affiliations

  1. Department of Immunology, The University of Birmingham, Birmingham, UK,Burn and Shock Trauma Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.

PMID: 19856302 DOI: 10.1080/15216549700203281

Abstract

Mycobacterium tuberculosis genes are expressed and screened in Mycobacterium smegmatis as a host, hence their survival in human monocytes needs to be determined. Strains of Mycobacterium smegmatis with an inactive catalase-peroxidase gene (KatG), or into which the KatG gene of Mycobacterium tuberculosis had been transfected, were used to study the influence of catalase on intracellular mycobacterial survival within human monocyte-derived macrophages. The five strains of Mycobacterium smegmatis were observed to grow at similar rates, irrespective of their catalase phenotype, within IFNgamma-treated or untreated human macrophage cultures, over a 3 day infection period. Moreover, there was no differential pattern of growth or inhibition among the strains of Mycobacterium smegmatis studied.

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