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Yin M, Guan X, Liao Z, et al. Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review. Am J Transl Res. 2009;1(2):101-14
Yin, M., Guan, X., Liao, Z., & Wei, Q. (2009). Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review. American journal of translational research, 1(2), 101-14.
Yin, Ming, et al. "Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review." American journal of translational research vol. 1,2 (2009): 101-14.
Yin M, Guan X, Liao Z, Wei Q. Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review. Am J Transl Res. 2009 Jan 30;1(2):101-14. PMID: 19956424; PMCID: PMC2776317.
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Am J Transl Res. 2009 Jan 30;1(2):101-14.

Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review.

American journal of translational research

Ming Yin, Xiaoxiang Guan, Zhongxin Liao, Qingyi Wei

PMID: 19956424 PMCID: PMC2776317

Abstract

Lung cancer leads all other cancers in both incidence and mortality. Recent advances in underlying molecular pathogenesis have validated a panel of protein tyrosine kinases as new targets in lung cancer treatment. Insulin-like growth factor-1 receptor (IGF-1R) is an important tyrosine kinase receptor involved in cell proliferation, differentiation, metabolism, apoptosis, and angiogenesis. Aberrant activation of IGF-1R is frequently found in patients with lung cancer and contributes to malignant transformation and poor prognosis for patients with lung cancer. In this review, we focused on recent progress in the research of IGF-1R's role in lung cancer development and progression, including its structure and biological function, potential mechanisms of aberrant activation, and related oncogenic effects. We also discussed effective IGF-1R antagonists that are currently registered for clinic trials or are undergoing preclinical study with special emphasis on their antibodies and small molecule tyrosine kinase inhibitors.

Keywords: Insulin-like growth factor; lung cancer; receptor; targeted therapy

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