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Wharton W, Gleason CE, Lorenze KR, et al. Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease. Am J Transl Res. 2009;1(2):131-47
Wharton, W., Gleason, C. E., Lorenze, K. R., Markgraf, T. S., Ries, M. L., Carlsson, C. M., & Asthana, S. (2009). Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease. American journal of translational research, 1(2), 131-47.
Wharton, Whitney, et al. "Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease." American journal of translational research vol. 1,2 (2009): 131-47.
Wharton W, Gleason CE, Lorenze KR, Markgraf TS, Ries ML, Carlsson CM, Asthana S. Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease. Am J Transl Res. 2009 Jan 20;1(2):131-47. PMID: 19956426; PMCID: PMC2776312.
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Am J Transl Res. 2009 Jan 20;1(2):131-47.

Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease.

American journal of translational research

Whitney Wharton, Carey E Gleason, Katelin R Lorenze, Tamara S Markgraf, Michele L Ries, Cynthia M Carlsson, Sanjay Asthana

PMID: 19956426 PMCID: PMC2776312

Abstract

Over a decade of converging findings from clinical, observational and basic science research indicate that estrogen administration during the menopausal transition exerts beneficial effects on cognition and decreases a woman's risk of developing Alzheimer's disease (AD) later in life. This review article stresses the research focus of AD prevention, and introduces hormone therapy (HT) as a probable catalyst that may achieve this goal. Furthermore, this article outlines 3 mechanisms proposed to mediate estrogen's beneficial effects, discusses the controversy surrounding HT administration, and presents the most promising estrogen related research in AD prevention and treatment. Although controversial, cumulative evidence suggests that the potential of estrogen initiated during perimenopause to prevent AD needs to be systematically evaluated.

Keywords: Alzheimer's disease; Estrogen; cognition; estrogen therapy; hormone therapy; postmenopausal cognition; women's health initiative

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